iso-α-Cyclopiazonic acid, a new natural product isolated from the marine-derived fungus Aspergillus flavus C-F-3

被引：44
|
作者：
Lin, Ai-Qun [1 ]
Du, Lin
Fang, Yu-Chun
Wang, Fa-Zuo
Zhu, Tian-Jiao
Gu, Qian-Qun
Zhu, Wei-Ming
机构：
[1] Ocean Univ China, Key Lab Marine Drugs, Chinese Minist Educ, Qingdao 266003, Peoples R China
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2009年 / 45卷 / 05期
关键词：
Aspergillus flavus; cyclopiazonic acid; cytotoxic activity; SARCOPLASMIC-RETICULUM; BIOSYNTHESIS; CELLS; ASSAY;
D O I：
10.1007/s10600-009-9433-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new natural product, iso-alpha-cyclopiazonic acid (1), together with its isomer alpha-cyclopiazonic acid (2); three mycotoxins: aflatoxin B-1 (AFB(1)) (3), aflatoxin Q(1) (AFQ(1)) (4), and O-methylsterigmatocystin (OMST) (5); two diketopiperazine alkaloids: ditryptophenaline (6) and 3-[(1H-indol-3-yl)methyl]-6-benzylpiperazine-2,5-dione (7), were isolated from the marine-derived fungus Aspergillus flavus. Their structures were determined by analysis of spectroscopic data. The cytotoxicities of compounds 1 and 2 were studied using HL-60, MOLT-4, A-549, and BEL-7402 cell lines.
引用
收藏
页码：677 / 680
页数：4
相关论文
共 50 条
  • [31] Speradines F-H, Three New Oxindole Alkaloids from the Marine-Derived Fungus Aspergillus oryzae
    Hu, Xiao
    Xia, Qi-Wen
    Zhao, Yang-Yang
    Zheng, Qiu-Hong
    Liu, Qin-Ying
    Chen, Li
    Zhang, Qi-Qing
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2014, 62 (09) : 942 - 946
  • [32] A New Diphenyl Ether from Marine-derived Fungus Aspergillus sp. B-F-2
    Rui Liu
    Weiming Zhu
    Yapeng Zhang
    Tianjiao Zhu
    Hongbing Liu
    Yuchun Fang
    Qianqun Gu
    The Journal of Antibiotics, 2006, 59 : 362 - 365
  • [33] New Thiodiketopiperazine and 3,4-Dihydroisocoumarin Derivatives from the Marine-Derived Fungus Aspergillus terreus
    Wu, Jing-Shuai
    Shi, Xiao-Hui
    Yao, Guang-Shan
    Shao, Chang-Lun
    Fu, Xiu-Mei
    Zhang, Xiu-Li
    Guan, Hua-Shi
    Wang, Chang-Yun
    MARINE DRUGS, 2020, 18 (03)
  • [34] 5-hydroxyramulosin, a new natural product produced by Phoma tropica, a marine-derived fungus isolated from the alga Fucus spiralis
    Osterhage, C
    König, GM
    Jones, PG
    Wright, AD
    PLANTA MEDICA, 2002, 68 (11) : 1052 - 1054
  • [35] Golmaenone, a new diketopiperazine alkaloid from the marine-derived fungus Aspergillus sp.
    Li, Y
    Li, XF
    Kim, SK
    Kang, JS
    Choi, HD
    Rho, JR
    Son, BW
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2004, 52 (03) : 375 - 376
  • [36] New rubrolides from the marine-derived fungus Aspergillus terreus OUCMDZ-1925
    Tonghan Zhu
    Zhengqian Chen
    Peipei Liu
    Yi Wang
    Zhihong Xin
    Weiming Zhu
    The Journal of Antibiotics, 2014, 67 : 315 - 318
  • [37] Parasitenone, a new epoxycyclohexenone related to gabosine from the marine-derived fungus Aspergillus parasiticus
    Son, BW
    Choi, JS
    Kim, JC
    Nam, KW
    Kim, DS
    Chung, HY
    Kang, JS
    Choi, HD
    JOURNAL OF NATURAL PRODUCTS, 2002, 65 (05): : 794 - 795
  • [38] Five Sesquiterpenoids from a Marine-Derived Fungus Aspergillus sp Isolated from a Gorgonian Dichotella gemmacea
    Wei, Mei-Yan
    Wang, Chang-Yun
    Liu, Qing-Ai
    Shao, Chang-Lun
    She, Zhi-Gang
    Lin, Yong-Cheng
    MARINE DRUGS, 2010, 8 (04) : 941 - 949
  • [39] Halogenated Anthraquinones from the Marine-Derived Fungus Aspergillus sp SCSIO F063
    Huang, Hongbo
    Wang, Fazuo
    Luo, Minghe
    Chen, Yuchan
    Song, Yongxiang
    Zhang, Weimin
    Zhang, Si
    Ju, Jianhua
    JOURNAL OF NATURAL PRODUCTS, 2012, 75 (07): : 1346 - 1352
  • [40] New rubrolides from the marine-derived fungus Aspergillus terreus OUCMDZ-1925
    Zhu, Tonghan
    Chen, Zhengqian
    Liu, Peipei
    Wang, Yi
    Xin, Zhihong
    Zhu, Weiming
    JOURNAL OF ANTIBIOTICS, 2014, 67 (04): : 315 - 318
12345