iso-α-Cyclopiazonic acid, a new natural product isolated from the marine-derived fungus Aspergillus flavus C-F-3

被引：45

作者：

Lin, Ai-Qun ^{[1
]}

Du, Lin

Fang, Yu-Chun

Wang, Fa-Zuo

Zhu, Tian-Jiao

Gu, Qian-Qun

Zhu, Wei-Ming

机构：

[1] Ocean Univ China, Key Lab Marine Drugs, Chinese Minist Educ, Qingdao 266003, Peoples R China

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2009年 / 45卷 / 05期

关键词：

Aspergillus flavus; cyclopiazonic acid; cytotoxic activity; SARCOPLASMIC-RETICULUM; BIOSYNTHESIS; CELLS; ASSAY;

D O I：

10.1007/s10600-009-9433-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new natural product, iso-alpha-cyclopiazonic acid (1), together with its isomer alpha-cyclopiazonic acid (2); three mycotoxins: aflatoxin B-1 (AFB(1)) (3), aflatoxin Q(1) (AFQ(1)) (4), and O-methylsterigmatocystin (OMST) (5); two diketopiperazine alkaloids: ditryptophenaline (6) and 3-[(1H-indol-3-yl)methyl]-6-benzylpiperazine-2,5-dione (7), were isolated from the marine-derived fungus Aspergillus flavus. Their structures were determined by analysis of spectroscopic data. The cytotoxicities of compounds 1 and 2 were studied using HL-60, MOLT-4, A-549, and BEL-7402 cell lines.

引用

页码：677 / 680

页数：4