Primary Sjogren's syndrome: Pathophysiological, clinical and therapeutic advances

被引：17

作者：

Gottenberg, J. -E. ^{[1
]}

机构：

[1] Hop Univ Strasbourg, Serv Rhumatol, Ctr Natl Reference Malad Autoimmunes Syst Rares, F-67000 Strasbourg, France

来源：

JOINT BONE SPINE | 2009年 / 76卷 / 06期

关键词：

Sjogren's syndrome; Primary; Disease activity score; B-lymphocytes; Interferons; Rituximab; SALIVARY-GLANDS; DOUBLE-BLIND; MONOCLONAL-ANTIBODY; RITUXIMAB; EXPRESSION; RISK; ACTIVATION; ALPHA; IRF5; BLYS;

D O I：

10.1016/j.jbspin.2009.09.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Primary Sjogren's syndrome was long a vexing dilemma, as the underlying pathophysiological mechanisms remained obscure, disease activity was challenging to evaluate, and no specific treatments were known to be effective. However, recent years have witnessed major advances in these three areas. Convincing evidence has been obtained that innate immunity, most notably mediated by the interferons, plays a role in the initial B-cell activation. A disease activity score was developed during a consensus conference sponsored by the EULAR. Even more importantly, B-cell depletion constitutes a highly promising therapeutic approach. Thus, rituximab was effective in two controlled clinical trials. (C) 2009 Published by Elsevier Masson SAS on behalf of the Societe Francaise de Rhumatologie.

引用

页码：591 / 594

页数：4

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