Clinical utility of FDG PET in Parkinson's disease and atypical parkinsonism associated with dementia

被引:80
作者
Walker, Zuzana [1 ,2 ]
Gandolfo, Federica [3 ]
Orini, Stefania [3 ]
Garibotto, Valentina [4 ]
Agosta, Federica [5 ]
Arbizu, Javier [6 ]
Bouwman, Femke [7 ,8 ]
Drzezga, Alexander [9 ,10 ]
Nestor, Peter [11 ,12 ,13 ]
Boccardi, Marina [14 ,15 ]
Altomare, Daniele [15 ,16 ]
Festari, Cristina [15 ,16 ]
Nobili, Flavio [17 ,18 ]
机构
[1] UCL, Div Psychiat, London, England
[2] St Margarets Hosp, Essex Partnership Univ NHS Fdn Trust, Epping CM16 6TN, England
[3] IRCCS S Giovanni Dio, Fatebenefratelli, Alzheimer Operat Unit, Brescia, Italy
[4] Univ Geneva, Univ Hosp Geneva, Dept Med Imaging, Div Nucl Med & Mol Imaging, Geneva, Switzerland
[5] Univ Vita Salute San Raffaele, San Raffaele Sci Inst, Inst Expt Neurol, Neuroimaging Res Unit,Div Neurosci, Milan, Italy
[6] Univ Navarra, Clin Univ Navarra, Dept Nucl Med, Pamplona, Spain
[7] Vrije Univ Amsterdam, Med Ctr, Dept Neurol, Amsterdam, Netherlands
[8] Vrije Univ Amsterdam, Med Ctr, Alzheimer Ctr, Amsterdam Neurosci, Amsterdam, Netherlands
[9] Univ Cologne, Univ Hosp Cologne, Dept Nucl Med, Cologne, Germany
[10] German Ctr Neurodegenerat Dis DZNE, Cologne, Germany
[11] German Ctr Neurodegenerat Dis DZNE, Magdeburg, Germany
[12] Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
[13] Mater Hosp Brisbane, Brisbane, Qld, Australia
[14] Univ Geneva, Dept Psychiat, LANVIE Lab Neuroimagerie Vieillissement, Geneva, Switzerland
[15] IRCCS S Giovanni Dio, Fatebenefratelli, LANE, Brescia, Italy
[16] Univ Brescia, Dept Mol & Translat Med, Brescia, Italy
[17] Univ Genoa, Dept Neurosci DINOGMI, Genoa, Italy
[18] Polyclin IRCCS San Martino IST, Neurol Clin, Genoa, Italy
关键词
FDG PET; Parkinson's disease; Progressive supranuclear palsy; Prodromal PD; Corticobasal syndrome; Corticobasal degeneration; PROGRESSIVE SUPRANUCLEAR PALSY; CEREBRAL GLUCOSE-METABOLISM; POSITRON-EMISSION-TOMOGRAPHY; DIFFERENTIAL-DIAGNOSIS; F-18-FDG PET; CORTICOBASAL SYNDROME; COGNITIVE IMPAIRMENT; BRAIN NETWORKS; PATTERNS; PSP;
D O I
10.1007/s00259-018-4031-2
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
There are no comprehensive guidelines for the use of FDG PET in the following three clinical scenarios: (1) diagnostic work-up of patients with idiopathic Parkinson's disease (PD) at risk of future cognitive decline, (2) discriminating idiopathic PD from progressive supranuclear palsy, and (3) identifying the underlying neuropathology in corticobasal syndrome. We therefore performed three literature searches and evaluated the selected studies for quality of design, risk of bias, inconsistency, imprecision, indirectness and effect size. Critical outcomes were the sensitivity, specificity, accuracy, positive/negative predictive value, area under the receiving operating characteristic curve, and positive/negative likelihood ratio of FDG PET in detecting the target condition. Using the Delphi method, a panel of seven experts voted for or against the use of FDG PET based on published evidence and expert opinion. Of 91 studies selected from the three literature searches, only four included an adequate quantitative assessment of the performance of FDG PET. The majority of studies lacked robust methodology due to lack of critical outcomes, inadequate gold standard and no head-to-head comparison with an appropriate reference standard. The panel recommended the use of FDG PET for all three clinical scenarios based on nonquantitative evidence of clinical utility. Despite widespread use of FDG PET in clinical practice and extensive research, there is still very limited good quality evidence for the use of FDG PET. However, in the opinion of the majority of the panellists, FDG PET is a clinically useful imaging biomarker for idiopathic PD and atypical parkinsonism associated with dementia.
引用
收藏
页码:1534 / 1545
页数:12
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