The Role of Alpha-MSH as a Modulator of Ocular Immunobiology Exemplifies Mechanistic Differences between Melanocortins and Steroids

被引:38
作者
Clemson, Christine M. [1 ]
Yost, John [1 ]
Taylor, Andrew W. [2 ]
机构
[1] Mallinckrodt Pharmaceut, Autoimmune & Rare Dis, Hayward, CA USA
[2] Boston Univ, Sch Med, Dept Ophthalmol, 72 East Concord St, Boston, MA 02118 USA
关键词
alpha-MSH; eye; glucocorticoids; melanocortins; MELANOCYTE-STIMULATING-HORMONE; REGULATORY T-CELLS; LENS EPITHELIAL-CELLS; CENTRAL SEROUS CHORIORETINOPATHY; EXPERIMENTAL AUTOIMMUNE UVEITIS; OPEN-ANGLE GLAUCOMA; GROWTH-FACTOR-BETA; GLUCOCORTICOID-INDUCED CHANGES; ELEVATED INTRAOCULAR-PRESSURE; RETINAL-PIGMENT EPITHELIUM;
D O I
10.3109/09273948.2015.1092560
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Melanocortins are a highly conserved family of peptides and receptors that includes multiple proopiomelanocortin-derived peptides and five defined melanocortin receptors. The melanocortins have an important role in maintaining immune homeostasis and in suppressing inflammation. Within the healthy eye, the melanocortins have a central role in preventing inflammation and maintaining immune privilege. A central mediator of the anti-inflammatory activity is the non-steroidogenic melanocortin peptide alpha-melanocyte stimulating hormone. In this review we summarize the major findings of melanocortin regulation of ocular immunobiology with particular interest in the ability of melanocortin to induce immune tolerance and cytoprotection. The melanocortins have therapeutic potential because their mechanisms of action in regulating immunity are distinctly different from the actions of steroids.
引用
收藏
页码:179 / 189
页数:11
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