Algerian Sonchus oleraceus L.: a comparison of different extraction solvent on phytochemical composition, antioxidant properties and anti-cholinesterase activity

被引：12

作者：

Aissani, Fatine ^{[1
]}

Grara, Nedjoud ^{[2
]}

Bensouici, Chawki ^{[3
]}

Bousbia, Aissam ^{[2
]}

Ayed, Hayette ^{[2
]}

Idris, Muhd Hanis Md ^{[4
,5
]}

Teh, Lay Kek ^{[4
,5
]}

机构：

[1] Univ 8 Mai 1945, Lab Biol Eau & Environm LBEE, PB 401, Guelma 24000, Algeria

[2] Univ 8 Mai 1945 Guelma, Fac Sci Nat & Vie & Sci Terre & Univers, PB 401, Guelma 24000, Algeria

[3] Biotechnol Res Ctr CRBT, Ali Mendjli New Town UV 03,PB E73, Constantine, Algeria

[4] Univ Teknol MARA UiTM Selangor, Integrat Pharmacogen Inst iPROMISE, Puncak Alam Campus, Bandar Puncak Alam 42300, Selangor, Malaysia

[5] Univ Teknol MARA UiTM Selangor, Fac Pharm, Puncak Alam Campus, Bandar Puncak Alam 42300, Selangor, Malaysia

来源：

ADVANCES IN TRADITIONAL MEDICINE | 2022年 / 22卷 / 02期

关键词：

LC-MS/QTOF; Sowthistle; Antioxidant; Anti-cholinesterase; Phenolic compounds;

D O I：

10.1007/s13596-021-00553-y

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aerial parts of Sonchus oleraceus L. were studied for the antioxidant and anti-cholinesterase activities in different solvent and fractions. Extracts/fractions were analysed for total phenolic, flavonoid and flavonol contents. The chemical constituents of the most active extracts/fractions were analysed using LC-MS/QTOF in the positive ion mode. Ethyl acetate and butanolic fractions exhibited the highest antioxidant activity in DPPH, galvinoxyl and phenanthroline assays due to high contents of phenolics, flavonoids and flavonols. Whereby total alkaloid extract had the highest scavenging activity in ABTS center dot+ assay. Besides, methanolic extract was noted for the highest inhibitory effect against acetylcholinesterase. Total 24 compounds were identified by LC-MS/QTOF which were phenolic acids, sesquiterpene lactones and phenylpropanoid derivatives. As conclusion, the study revealed that the aerial parts of S. oleraceus are potential sources of natural antioxidant and anti-cholinesterase compounds.

引用

页码：383 / 394

页数：12

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