pfk13-Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom

被引：0
|
作者：
Sutherland, Colin J. [1 ,2 ]
Lansdell, Paul [1 ]
Sanders, Mandy [3 ]
Muwanguzi, Julian [2 ]
van Schalkwyk, Donelly A. [2 ]
Kaur, Harparkash [2 ]
Nolder, Debbie [1 ]
Tucker, Julie [1 ]
Bennett, Hayley M. [3 ]
Otto, Thomas D. [3 ]
Berriman, Matthew [3 ]
Patel, Trupti A. [4 ]
Lynn, Roderick [5 ]
Gkrania-Klotsas, Effrossyni [6 ]
Chiodini, Peter L. [1 ,4 ]
机构：
[1] London Sch Hyg & Trop Med, Publ Hlth England Malaria Reference Lab, London, England
[2] London Sch Hyg & Trop Med, Dept Immunol & Infect, Fac Infect & Trop Dis, London, England
[3] Wellcome Trust Sanger Inst, Hinxton, England
[4] Hosp Trop Dis, London, England
[5] Cambridge Univ Hosp NHS Fdn Trust, Addenbrookes Hosp, Dept Haematol, Cambridge, England
[6] Cambridge Univ Hosp NHS Fdn Trust, Dept Infect Dis, Addenbrookes Hosp, Cambridge, England
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 03期
基金：
英国惠康基金;
关键词：
imported malaria; treatment failure; parasite genotyping; antimalarial agents; drug resistance mechanisms; UNCOMPLICATED MALARIA; ARTEMISININ; RESISTANCE;
D O I：
10.1128/AAC.02382-16
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We present case histories of four patients treated with artemether-lumefantrine for falciparum malaria in UK hospitals in 2015 to 2016. Each subsequently presented with recurrent symptoms and Plasmodium falciparum parasitemia within 6 weeks of treatment with no intervening travel to countries where malaria is endemic. Parasite isolates, all of African origin, harbored variants at some candidate resistance loci. No evidence of pfk13-mediated artemisinin resistance was found. Vigilance for signs of unsatisfactory antimalarial efficacy among imported cases of malaria is recommended.
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