The role of ADRB2 gene polymorphisms in malignancies

被引：20
作者：
Wang, Yaqian [1 ]
Jiang, Shujuan [1 ,2 ,3 ]
机构：
[1] Shandong Univ, Shandong Prov Hosp, Cheeloo Coll Med, Dept Resp & Crit Care Med, Jingwu Rd 324, Jinan 250021, Shandong, Peoples R China
[2] Shandong First Med Univ, Shandong Prov Hosp, Dept Resp & Crit Care Med, Jinan 250021, Shandong, Peoples R China
[3] Shandong Key Lab Infect Resp Dis, Jinan 250021, Shandong, Peoples R China
来源：
MOLECULAR BIOLOGY REPORTS | 2021年 / 48卷 / 03期
关键词：
ADRB2; Malignancy; Single nucleotide polymorphism; β (2)-Adrenergic receptor; BETA-2-ADRENERGIC RECEPTOR GENE; CELL LUNG-CANCER; SINGLE NUCLEOTIDE POLYMORPHISMS; 5' LEADER CISTRON; BETA-BLOCKERS; BREAST-CANCER; PROMOTER POLYMORPHISMS; ANTAGONIST PROPRANOLOL; SMOOTH-MUSCLE; KAPPA-B;
D O I：
10.1007/s11033-021-06250-y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Beta-2-adrenergic receptor is a member of the G protein-coupled receptor superfamily, which is highly expressed in most malignancies. There is increasing evidence showing that beta-2-adrenergic receptors are associated with carcinogenesis, proliferation, immune regulation, invasion, angiogenesis, clinical prognosis and treatment resistance in malignancies. Polymorphisms of the ADRB2 gene have been confirmed to be associated with transcriptional activity, mRNA translation, and beta-2-adrenergic receptor expression and sensitivity. This review discusses clinically relevant examples of single nucleotide polymorphisms of ADRB2 in malignancies and the effects of these polymorphisms on cancer susceptibility, prognosis and treatment response of cancer patients.
引用
收藏
页码：2741 / 2749
页数：9
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