A model of diffusion-influenced enzyme activation

被引：5
|
作者：
Molski, A [1 ]
机构：
[1] Adam Mickiewicz Univ, Dept Phys Chem, PL-60780 Poznan, Poland
来源：
JOURNAL OF PHYSICAL CHEMISTRY B | 2000年 / 104卷 / 18期
关键词：
D O I：
10.1021/jp9935844
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The kinetics of a model of diffusion-influenced enzyme activation is studied in two spatial dimensions. Enzyme molecules diffuse and collide with an immobile, spherical, uniformly reactive receptor-ligand complex. Enzymes do not interact with each other, but interact with the complex via an interparticle potential. No hydrodynamic interactions are included. Inactive enzymes get activated upon collisions with the complex. Enzyme deactivation is modeled as a first-order kinetic process independent of diffusion and collisions, Exact expressions are derived for the steady-state number of active enzymes and for the Laplace transform of the time-dependent activation rate coefficient. The activation kinetics in the time domain can be calculated by numerical inversion of the kinetic expressions in Laplace space.
引用
收藏
页码：4532 / 4536
页数：5
相关论文
共 50 条
  • [11] FLUCTUATION AND ROTATION IN DIFFUSION-INFLUENCED MONOMOLECULAR REACTIONS
    BASHFORD, D
    JOURNAL OF CHEMICAL PHYSICS, 1986, 85 (12): : 6999 - 7010
  • [12] ASYMPTOTIC ANALYSIS OF DIFFUSION-INFLUENCED KINETICS WITH A POTENTIAL
    GREEN, NJB
    PIMBLOTT, SM
    JOURNAL OF PHYSICAL CHEMISTRY, 1989, 93 (14): : 5462 - 5467
  • [13] Memory equations for kinetics of diffusion-influenced reactions
    Department of Chemistry, Basic Sciences Research Institute, Chungbuk National University, Cheongju 361-763, Korea, Republic of
    Bull. Korean Chem. Soc., 2006, 10 (1659-1663):
  • [14] Diffusion-influenced kinetics of reactions involving polymers
    Sung, J
    Park, PJ
    Lee, J
    Lee, W
    Kim, JH
    Lee, S
    BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2003, 24 (06) : 843 - 852
  • [15] Theory of diffusion-influenced reactions in complex geometries
    Galanti, Marta
    Fanelli, Duccio
    Traytak, Sergey D.
    Piazza, Francesco
    PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2016, 18 (23) : 15950 - 15954
  • [16] The intrinsic rate constants in diffusion-influenced reactions
    Vijaykumar, Adithya
    Bolhuis, Peter G.
    ten Wolde, Pieter Rein
    FARADAY DISCUSSIONS, 2016, 195 : 421 - 441
  • [17] Memory equations for kinetics of diffusion-influenced reactions
    Yang, Mino
    BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2006, 27 (10) : 1659 - 1663
  • [18] REVERSIBLE DIFFUSION-INFLUENCED REACTIONS - COMPARISON OF THEORY AND SIMULATION FOR A SIMPLE-MODEL
    SZABO, A
    ZWANZIG, R
    JOURNAL OF STATISTICAL PHYSICS, 1991, 65 (5-6) : 1057 - 1083
  • [19] Computational methods for diffusion-influenced biochemical reactions
    Dobrzynski, Maciej
    Rodriguez, Jordi Vidal
    Kaandorp, Jaap A.
    Blom, Joke G.
    BIOINFORMATICS, 2007, 23 (15) : 1969 - 1977
  • [20] Reversible Stochastically Gated Diffusion-Influenced Reactions
    Gopich, Irina V.
    Szabo, Attila
    JOURNAL OF PHYSICAL CHEMISTRY B, 2016, 120 (33): : 8080 - 8089
12345