New flavonoid glycosides from Xanthium strumarium with their protein tyrosine phosphatase 1B inhibitory activity

被引：6

作者：

Jiang, Pei-Jing ^{[1
]}

Lu, Mei-Jiao ^{[2
]}

Xi, Yi-Yuan ^{[3
]}

Chen, Jun ^{[1
]}

Zheng, Ju-Jia ^{[3
]}

Xu, Xiang-Wei ^{[1
]}

机构：

[1] First Peoples Hosp Yongkang, Dept Pharm, Yongkang 321300, Peoples R China

[2] Peoples Hosp Jinyun, Dept Pharm, Jinyun 321400, Peoples R China

[3] Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2022年 / 24卷 / 01期

关键词：

Xanthium strumarium; Compositae; flavonoid glycosides; PTP1B;

D O I：

10.1080/10286020.2021.1873957

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new flavonoid glycosides named 6-hydroxy-3-methoxy-apigenin 7-O-alpha-x29f;-rhamnopyranoside (1) and 3-hydroxyl-apigenin 8-C-beta-x1d05;-xylopyranoside (2), along with five known compounds (3-7), were isolated from Xanthium strumarium. Their structures were elucidated on the basis of spectroscopic and physicochemical analyses. All compounds were evaluated for in vitro inhibitory activity against PTP1B. Among them, compounds 1 and 5 showed significant inhibitory activity on PTP1B with IC50 values of 11.3 +/- 1.7 and 8.9 +/- 0.7 mu M, respectively. [GRAPHICS] .

引用

页码：45 / 51

页数：7

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