Mitochondrial Calcium Uniporter Structure and Function in Different Types of Muscle Tissues in Health and Disease

被引：17
|
作者：
Tarasova, Nadezhda V. [1 ]
Vishnyakova, Polina A. [2 ]
Logashina, Yulia A. [1 ,3 ]
Elchaninov, Andrey V. [2 ,4 ,5 ]
机构：
[1] Sechenov First Moscow State Med Univ, Inst Mol Med, Trubetskaya Str 8,Bld 2, Moscow 119991, Russia
[2] Minist Healthcare Russian Federat, Natl Med Res Ctr Obstet Gynecol & Perinatol, 4 Oparina St, Moscow 117997, Russia
[3] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Miklukho Maklaya St 16-10, Moscow 117997, Russia
[4] Sci Res Inst Human Morphol, 3 Tsurupa St, Moscow 117418, Russia
[5] Peoples Friendship Univ Russia, 6 Miklukho Maklaya St, Moscow 117198, Russia
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 19期
关键词：
calcium; calcium signaling; mitochondrial calcium uniporter; calcium homeostasis; regulatory pathways; myocardium; skeletal muscle; smooth muscle; CA2+ UNIPORTER; STRESS RESPONSES; SKELETAL-MUSCLE; MICE LACKING; MCU COMPLEX; HOMEOSTASIS; ACTIVATION; INHIBITION; UCP2; PHOSPHORYLATION;
D O I：
10.3390/ijms20194823
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Calcium ions (Ca2+) influx to mitochondrial matrix is crucial for the life of a cell. Mitochondrial calcium uniporter (mtCU) is a protein complex which consists of the pore-forming subunit (MCU) and several regulatory subunits. MtCU is the main contributor to inward Ca2+ currents through the inner mitochondrial membrane. Extensive investigations of mtCU involvement into normal and pathological molecular pathways started from the moment of discovery of its molecular components. A crucial role of mtCU in the control of these pathways is now recognized in both health and disease. In particular, impairments of mtCU function have been demonstrated for cardiovascular and skeletal muscle-associated pathologies. This review summarizes the current state of knowledge on mtCU structure, regulation, and function in different types of muscle tissues in health and disease.
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页数：26
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