Synthesis of an Arginine Tagged [Cys155-Arg180] Fragment of NY-ESO-1: Elimination of an Undesired By-product Using 'In House' Resins

被引：21

作者：

Harris, Paul W. R. ^{[1
]}

Brimble, Margaret A. ^{[1
]}

机构：

[1] Univ Auckland, Dept Chem, Auckland 1142, New Zealand

来源：

SYNTHESIS-STUTTGART | 2009年 / 20期

关键词：

solid-phase; resins; HMBA linker; arginine tag; PHASE PEPTIDE-SYNTHESIS; AMINO-ACIDS; CLEAVAGE;

D O I：

10.1055/s-0029-1216952

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

During the solid-phase synthesis of a peptide fragment derived from the cancer protein NY-ESO-1 incorporating a solubilising arginine tag, a significant by-product was obtained that lacked the arginine tag. The formation of this by-product (and others) was highly dependant on the quality of the resin used and was completely removed when the resin was synthesized 'in house'.

引用

页码：3460 / 3466

页数：7

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