Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

被引：266

作者：

Tin, Adrienne ^{[1
,2
]}

Marten, Jonathan ^{[3
]}

Kuhns, Victoria L. Halperin ^{[4
]}

Li, Yong ^{[5
,6
]}

Wuttke, Matthias ^{[5
,6
]}

Kirsten, Holger ^{[7
,8
]}

Sieber, Karsten B. ^{[9
]}

Qiu, Chengxiang ^{[10
]}

Gorski, Mathias ^{[11
,12
]}

Yu, Zhi ^{[1
,13
]}

Giri, Ayush ^{[14
,15
]}

Sveinbjornsson, Gardar ^{[16
]}

Li, Man ^{[17
]}

Chu, Audrey Y. ^{[18
]}

Hoppmann, Anselm ^{[5
,6
]}

O'Connor, Luke J. ^{[19
]}

Prins, Bram ^{[20
]}

Nutile, Teresa ^{[21
]}

Noce, Damia ^{[22
]}

Akiyama, Masato ^{[23
,24
]}

Cocca, Massimiliano ^{[25
]}

Ghasemi, Sahar ^{[26
,27
]}

van Der Most, Peter J. ^{[28
]}

Horn, Katrin ^{[7
,8
]}

Xu, Yizhe ^{[17
]}

Fuchsberger, Christian ^{[22
]}

Sedaghat, Sanaz ^{[29
]}

Afaq, Saima ^{[30
,31
]}

Amin, Najaf ^{[29
]}

Arnlov, Johan ^{[32
,33
]}

Bakker, Stephan J. L. ^{[34
]}

Bansal, Nisha ^{[35
,36
]}

Baptista, Daniela ^{[37
]}

Bergmann, Sven ^{[38
,39
,40
]}

Biggs, Mary L. ^{[41
,42
]}

Biino, Ginevra ^{[43
]}

Boerwinkle, Eric ^{[44
]}

Bottinger, Erwin P. ^{[45
]}

Boutin, Thibaud S. ^{[3
]}

Brumat, Marco ^{[46
]}

Burkhardt, Ralph ^{[8
,47
,48
]}

Campana, Eric ^{[46
]}

Campbell, Archie ^{[49
]}

Campbell, Harry ^{[50
]}

Carroll, Robert J. ^{[51
]}

Catamo, Eulalia ^{[25
]}

Chambers, John C. ^{[30
,52
,53
,54
,55
]}

Ciullo, Marina ^{[21
,56
]}

Concas, Maria Pina ^{[25
]}

Coresh, Josef ^{[1
]}

机构：

[1] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA

[2] Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD 21205 USA

[3] Univ Edinburgh, Inst Genet & Mol Med, MRC, Human Genet Unit, Edinburgh, Midlothian, Scotland

[4] Univ Maryland, Sch Med, Dept Physiol, Baltimore, MD 21201 USA

[5] Univ Freiburg, Inst Genet Epidemiol, Dept Biometry Epidemiol & Med Bioinformat, Fac Med, Freiburg, Germany

[6] Univ Freiburg, Med Ctr, Freiburg, Germany

[7] Univ Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany

[8] Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany

[9] GlaxoSmithKline, Target Sci Genet, Collegeville, PA USA

[10] Univ Penn, Dept Med & Genet, Philadelphia, PA 19104 USA

[11] Univ Hosp Regensburg, Dept Nephrol, Regensburg, Germany

[12] Univ Regensburg, Dept Genet Epidemiol, Regensburg, Germany

[13] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Biostat, Baltimore, MD USA

[14] Vanderbilt Univ, Med Ctr, Inst Med & Publ Hlth,Div Quantitat Sci,Dept Obste, Vanderbilt Genet Inst,Vanderbilt Epidemiol Ctr, Nashville, TN USA

[15] Vanderbilt Univ, Biomed Lab Res & Dev, Tennessee Valley Healthcare Syst 626, Nashville, TN USA

[16] Amgen Inc, deCODE Genet, Reykjavik, Iceland

[17] Univ Utah, Dept Med, Div Nephrol & Hypertens, Salt Lake City, UT 84112 USA

[18] Merck & Co Inc, Genet, Kenilworth, NJ USA

[19] Harvard TH Chan Sch Publ Hlth, Epidemiol, Boston, MA USA

[20] Univ Cambridge, Strangeways Res Lab, Cambridge, England

[21] CNR, Inst Genet & Biophys Adriano Buzzati Traverso, Naples, Italy

[22] Inst Biomed, Eurac Res, Bolzano, Italy

[23] RIKEN, Lab Stat Anal, Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan

[24] Kyushu Univ, Grad Sch Med Sci, Dept Ophthalmol, Fukuoka, Fukuoka, Japan

[25] IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy

[26] Univ Med Greifswald, Inst Community Med, Greifswald, Germany

[27] DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany

[28] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands

[29] Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands

[30] Imperial Coll London, Fac Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[31] Khyber Med Univ, Inst Publ Hlth & Social Sci, Peshawar, Pakistan

[32] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med & Primary Care, Stockholm, Sweden

[33] Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden

[34] Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Div Nephrol, Groningen, Netherlands

[35] Univ Washington, Div Nephrol, Seattle, WA 98195 USA

[36] Univ Washington, Kidney Res Inst, Seattle, WA 98195 USA

[37] Geneva Univ Hosp, Cardiol, Geneva, Switzerland

[38] Univ Lausanne, Dept Computat Biol, Lausanne, Switzerland

[39] Swiss Inst Bioinformat, Lausanne, Switzerland

[40] Univ Cape Town, Dept Integrat Biomed Sci, Cape Town, South Africa

[41] Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA

[42] Univ Washington, Dept Biostat, Seattle, WA 98195 USA

[43] Natl Res Council Italy, Inst Mol Genet, Pavia, Italy

[44] Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Houston, TX 77030 USA

[45] Icahn Sch Med Mt Sinai, Hasso Plattner Inst Digital Hlth Mt Sinai, New York, NY 10029 USA

[46] Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy

[47] Univ Leipzig, Inst Lab Med Clin Chem & Mol Diagnost, Leipzig, Germany

[48] Univ Hosp Regensburg, Inst Clin Chem & Lab Med, Regensburg, Germany

[49] Univ Edinburgh, Ctr Genom & Expt Med, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland

[50] Univ Edinburgh, Ctr Global Hlth Res, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland

来源：

NATURE GENETICS | 2019年 / 51卷 / 10期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

GENOME-WIDE ASSOCIATION; LD SCORE REGRESSION; URIC-ACID LEVELS; R PACKAGE; KIDNEY-FUNCTION; FACTOR-BINDING; LOCI; GOUT; RISK; TRAITS;

D O I：

10.1038/s41588-019-0504-x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly understood mechanisms. We performed a trans-ancestry genome-wide association study of serum urate in 457,690 individuals, identifying 183 loci (147 previously unknown) that improve the prediction of gout in an independent cohort of 334,880 individuals. Serum urate showed significant genetic correlations with many cardiometabolic traits, with genetic causality analyses supporting a substantial role for pleiotropy. Enrichment analysis, fine-mapping of urate-associated loci and colocalization with gene expression in 47 tissues implicated the kidney and liver as the main target organs and prioritized potentially causal genes and variants, including the transcriptional master regulators in the liver and kidney, HNF1A and HNF4A. Experimental validation showed that HNF4A transactivated the promoter of ABCG2, encoding a major urate transporter, in kidney cells, and that HNF4A p.Thr139Ile is a functional variant. Transcriptional coregulation within and across organs may be a general mechanism underlying the observed pleiotropy between urate and cardiometabolic traits.

引用

页码：1459 / +

页数：19

共 109 条

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[Anonymous], PLOS GENET

[2]

[Anonymous], 2012, Nature

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