Smoking, APOE Genotype, and Cognitive Decline: The Rotterdam Study

被引：16
|
作者：
Wingbermuhle, Robin [1 ]
Wen, Ke-xin [1 ]
Wolters, Frank J. [1 ,2 ]
Ikram, M. Arfan [1 ,2 ,3 ]
Bos, Daniel [1 ,3 ]
机构：
[1] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands
[2] Erasmus MC, Dept Neurol, Rotterdam, Netherlands
[3] Erasmus MC, Dept Radiol & Nucl Med, Rotterdam, Netherlands
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2017年 / 57卷 / 04期
关键词：
APOE epsilon 4 genotype; cognitive decline; epidemiology; smoking; CARDIOVASCULAR RISK; ALZHEIMERS-DISEASE; DEMENTIA; METAANALYSIS; CESSATION; MORTALITY;
D O I：
10.3233/JAD-170063
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The association of smoking with preclinical cognitive decline remains unclear and may be modified by the APOE epsilon 4 genotype. In 5,705 participants (mean age: 63.9 +/- 9.1 years; 57.4% women) from the population-based Rotterdam Study, we investigated the relationship between smoking and cognitive decline over a 5.5-year period and examined potential effect modification by APOE epsilon 4 genotype. We found that current smoking was related to decline in global cognition [ difference compared to never smoking: -0.06 (95% C.I.-0.10;-0.01)],as well as decline on specific cognitive tests including the Letter Digit Substitution Task, the 15-Word Learning Test, and the Purdue Pegboard. We found no evidence for effect modification by APOE epsilon 4 genotype on this relation.
引用
收藏
页码：1191 / 1195
页数：5
相关论文
共 50 条
  • [41] Accounting for Bias Due to Selective Attrition The Example of Smoking and Cognitive Decline
    Weuve, Jennifer
    Tchetgen, Eric J. Tchetgen
    Glymour, M. Maria
    Beck, Todd L.
    Aggarwal, Neelum T.
    Wilson, Robert S.
    Evans, Denis A.
    de Leon, Carlos F. Mendes
    EPIDEMIOLOGY, 2012, 23 (01) : 119 - 128
  • [42] Functional MRI and ApoE4 genotype for predicting cognitive decline in amyloid-positive individuals
    Zhu, Jun-Ding
    Huang, Chi-Wei
    Chang, Hsin-, I
    Tsai, Shih-Jen
    Huang, Shu-Hua
    Hsu, Shih-Wei
    Lee, Chen-Chang
    Chen, Hong-Jie
    Chang, Chiung-Chih
    Yang, Albert C. C.
    THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS, 2022, 15
  • [43] APOE ε2ε4 genotype, incident AD and MCI, cognitive decline, and AD pathology in older adults
    Oveisgharan, Shahram
    Buchman, Aron S.
    Yu, Lei
    Farfel, Jose
    Hachinski, Vladimir
    Gaiteri, Chris
    De Jager, Philip L.
    Schneider, Julie A.
    Bennett, David A.
    NEUROLOGY, 2018, 90 (24) : E2127 - E2134
  • [44] Disturbed Sleep Patterns in Elders with Mild Cognitive Impairment: The Role of Memory Decline and ApoE ε4 Genotype
    Hita-Yanez, Eva
    Atienza, Mercedes
    Gil-Neciga, Eulogio
    Cantero, Jose L.
    CURRENT ALZHEIMER RESEARCH, 2012, 9 (03) : 290 - 297
  • [45] The Effects of Subjective Cognitive Decline on APOE Genotype Disclosure in the Butler Hospital Alzheimer's Prevention Registry
    Lee, A. K. W.
    Collier, M. K.
    Thompson, L. I.
    Popescu, D.
    Arthur, E.
    Correia, S.
    Salloway, S. P.
    Alber, J.
    JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE, 2023, 10 (02): : 152 - 161
  • [46] The Effects of Subjective Cognitive Decline on APOE Genotype Disclosure in the Butler Hospital Alzheimer’s Prevention Registry
    Athene K. W. Lee
    M. K. Collier
    L. I. Thompson
    D. Popescu
    E. Arthur
    S. Correia
    S. P. Salloway
    J. Alber
    The Journal of Prevention of Alzheimer's Disease, 2023, 10 : 152 - 161
  • [47] The Role of Smoking, Obesity, and Physical Inactivity in Cognitive Performance and Decline: A Multicohort Study
    Hong, Chenlu
    Liu, Zhaorui
    Liu, Yating
    Jin, Yinzi
    Luo, Yanan
    JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2024, 79 (02):
  • [48] The influence of APOE status on rate of cognitive decline
    Morrison, Cassandra
    Oliver, Michael D.
    Berry, Virginia
    Kamal, Farooq
    Dadar, Mahsa
    GEROSCIENCE, 2024, 46 (3) : 3263 - 3274
  • [49] Relative telomere length and cognitive decline in the Nurses' Health Study
    Devore, Elizabeth E.
    Prescott, Jennifer
    De Vivo, Immaculata
    Grodstein, Francine
    NEUROSCIENCE LETTERS, 2011, 492 (01) : 15 - 18
  • [50] Age and Apolipoprotein E Genotype Influence Rate of Cognitive Decline in Nondemented Elderly
    Salmon, David P.
    Ferris, Steven H.
    Thomas, Ronald G.
    Sano, Mary
    Cummings, Jeffery L.
    Sperling, Reisa A.
    Petersen, Ronald C.
    Aisen, Paul S.
    NEUROPSYCHOLOGY, 2013, 27 (04) : 391 - 401
12345