Mycophenolate mofetil: What is its place in the treatment of autoimmune rheumatic diseases?

被引：67
作者：
Iaccarino, Luca
Rampudda, Mariaelisa
Canova, Mariagrazia
Della Libera, Sara
Sarzi-Puttinic, Piercarlo
Doria, Andrea
机构：
[1] Univ Padua, Div Rheumatol, Dept Clin & Expt Med, I-35128 Padua, Italy
[2] Hosp San Dona di Piave, Div Med, Venice, Italy
[3] L Sacco Univ Hosp, Rheumatol Unit, Milan, Italy
来源：
AUTOIMMUNITY REVIEWS | 2007年 / 6卷 / 03期
基金：
美国国家科学基金会;
关键词：
mycophenolate mofetil; systemic lupus erythematosus; systemic sclerosis; systemic vasculitis; inflammatory arthropathies; idiopathic inflammatory myopathies;
D O I：
10.1016/j.autrev.2006.11.001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Mycophenolate mofetil (MMF) is a new immunosuppressant recently introduced in the treatment of autoimmune conditions. The greatest experience with the use of MMF has been achieved in the treatment of proliferative lupus glomerulonephtitis. However, MMF has also been used to control SLE extra-renal manifestations as well as other autoimmune rheumatic diseases such as idiopathic inflammatory arthropathies, inflammatory myopathies, systemic sclerosis, and systemic vasculitis. MMF seems to be well tolerated and effective and could be considered a useful alternative to standard immunosuppressants for the treatment of autoimmune rheumatic disorders. However, further studies are needed in order to determine its real place in the treatment of these conditions. In this paper, the use of MMF in different autoimmune rheumatic diseases is reviewed and discussed. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：190 / 195
页数：6
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