Assessing the Potential for Unintended Microbial Consequences of Routine Chlorhexidine Bathing for Prevention of Healthcare-associated Infections

被引：16
作者：
Babiker, Ahmed [1 ,2 ]
Lutgring, Joseph D. [3 ]
Fridkin, Scott [1 ]
Hayden, Mary K. [4 ,5 ]
机构：
[1] Emory Univ, Div Infect Dis, Sch Med, Atlanta, GA 30322 USA
[2] Emory Univ, Dept Pathol & Lab Med, Sch Med, Atlanta, GA 30322 USA
[3] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA
[4] Rush Univ, Dept Internal Med Infect Dis, Med Ctr, Chicago, IL USA
[5] Rush Univ, Dept Pathol, Med Ctr, Chicago, IL USA
来源：
CLINICAL INFECTIOUS DISEASES | 2021年 / 72卷 / 05期
关键词：
chlorhexidine gluconate; healthcare-associated infections; decolonization; antibiotic resistance; antiseptic; RESISTANT STAPHYLOCOCCUS-AUREUS; BLOOD-STREAM INFECTIONS; METHICILLIN-RESISTANT; ANTISEPTIC-RESISTANCE; KLEBSIELLA-PNEUMONIAE; REDUCED SUSCEPTIBILITY; HAND HYGIENE; GENES QACA; ANTIMICROBIAL RESISTANCE; ANTIBIOTIC-RESISTANCE;
D O I：
10.1093/cid/ciaa1103
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Chlorhexidine gluconate (CHG) is an antiseptic that is widely used in healthcare due to its excellent safety profile and wide spectrum of activity. Daily bathing with CHG has proven to be effective in the prevention of healthcare-associated infections and multidrug-resistant pathogen decolonization. Despite the proven benefits of CHG use, there remain concerns and unanswered questions about the potential for unintended microbial consequences of routine CHG bathing. This review aims to explore some of these questions.
引用
收藏
页码：891 / 898
页数：8
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  • [1] In vitro efficacy of disinfectants utilised for skin decolonisation and environmental decontamination during a hospital outbreak with Candida auris
    Abdolrasouli, Alireza
    Armstrong-James, Darius
    Ryan, Lisa
    Schelenz, Silke
    [J]. MYCOSES, 2017, 60 (11) : 758 - 763
  • [2] Klebsiella pneumoniae susceptibility to biocides and its association with cepA, qacΔE and qacE efflux pump genes and antibiotic resistance
    Abuzaid, A.
    Hamouda, A.
    Amyes, S. G. B.
    [J]. JOURNAL OF HOSPITAL INFECTION, 2012, 81 (02) : 87 - 91
  • [3] Analysis on distribution and genomic diversity of high-level antiseptic resistance genes qacA and qacB in human clinical isolates of Staphylococcus aureus
    Alam, MM
    Kobayashi, N
    Uehara, N
    Watanabe, N
    [J]. MICROBIAL DRUG RESISTANCE, 2003, 9 (02) : 109 - 121
  • [4] Chlorhexidine gluconate bathing practices and skin concentrations in intensive care unit patients
    Alserehi, Haleema
    Filippell, Mala
    Emerick, Michele
    Cabunoc, Marie Kristine
    Preas, Michael Anne
    Sparkes, Corey
    Johnson, J. Kristie
    Leekha, Surbhi
    [J]. AMERICAN JOURNAL OF INFECTION CONTROL, 2018, 46 (02) : 226 - 228
  • [5] Increase in Chlorhexidine Minimal Inhibitory Concentration of Acinetobacter baumannii Clinical Isolates after Implementation of Advanced Source Control
    Apisarnthanarak, Anucha
    Hsu, Li Yang
    Lim, Tze-Peng
    Mundy, Linda M.
    [J]. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2014, 35 (01) : 98 - 99
  • [6] Use of online tools for antimicrobial resistance prediction by whole-genome sequencing in methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE)
    Babiker, Ahmed
    Mustapha, Mustapha M.
    Pacey, Marissa P.
    Shutt, Kathleen A.
    Ezeonwuka, Chinelo D.
    Ohm, Sara L.
    Cooper, Vaughn S.
    Marsh, Jane W.
    Doi, Yohei
    Harrison, Lee H.
    [J]. JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, 2019, 19 : 136 - 143
  • [7] Efficacy and Limitation of a Chlorhexidine-Based Decolonization Strategy in Preventing Transmission of Methicillin-Resistant Staphylococcus aureus in an Intensive Care Unit
    Batra, Rahul
    Cooper, Ben S.
    Whiteley, Craig
    Patel, Amita K.
    Wyncoll, Duncan
    Edgeworth, Jonathan D.
    [J]. CLINICAL INFECTIOUS DISEASES, 2010, 50 (02) : 210 - 217
  • [8] Reduced Chlorhexidine and Daptomycin Susceptibility in Vancomycin-Resistant Enterococcus faecium after Serial Chlorhexidine Exposure
    Bhardwaj, Pooja
    Hans, Amrita
    Ruikar, Kinnari
    Guan, Ziqiang
    Palmer, Kelli L.
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2018, 62 (01)
  • [9] Effectiveness of chlorhexidine bathing to reduce catheter-associated bloodstream infections in medical intensive care unit patients
    Bleasdale, Susan C.
    Trick, William E.
    Gonzalez, Ines M.
    Lyles, Rosie D.
    Hayden, Mary K.
    Weinstein, Robert A.
    [J]. ARCHIVES OF INTERNAL MEDICINE, 2007, 167 (19) : 2073 - 2079
  • [10] Varying activity of chlorhexidine-based disinfectants against Klebsiella pneumoniae clinical isolates and adapted strains
    Bock, L. J.
    Wand, M. E.
    Sutton, J. M.
    [J]. JOURNAL OF HOSPITAL INFECTION, 2016, 93 (01) : 42 - 48
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