The repressive effect of green tea ingredients on amyloid precursor protein (APP) expression in oral carcinoma cells in vitro and in vivo

被引：15
作者：
Ko, Shun-Yao
Chang, Kuo-Wei
Lin, Shu-Chun
Hsu, Hui-Chuan
Liu, Tsung-Yun
机构：
[1] Vet Gen Hosp, Dept Med Res & Educ, Taipei 112, Taiwan
[2] Natl Yang Ming Univ, Sch Dent, Taipei 112, Taiwan
[3] Dept Hlth Execut, Bur Food & Drug Anal, Taipei, Taiwan
[4] Natl Yang Ming Univ, Inst Pharmacol, Taipei 112, Taiwan
来源：
CANCER LETTERS | 2007年 / 245卷 / 1-2期
关键词：
APP; cancer; carcinogenesis; mouth; tea;
D O I：
10.1016/j.canlet.2005.12.029
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In a hamster model of N-methyl-N-benzylnitrosamine (MBN)-induced oral carcinogenesis, the incidence of buccal pouch (HBP) carcinomas in MBN-treated hamsters (17.8 +/- 7.5) was significantly higher than MBN-treated hamsters given tea (10.8 +/- 3.9) (P < 0.05). Amyloid precursor protein (APP) expression was also significantly increased in MBN-induced HBP carcinomas but was significantly reduced by tea intake (P < 0.0001). Furthermore, APP expression and secretion by OECM-1 oral squamous cell carcinoma cells was inhibited by a major polyphenolic ingredient of green tea, (-)-epigallocatechin gallate, in a dose-dependent manner. Thus, APP might promote oral carcinogenesis, whereas green tea ingredients might diminish it by down-regulating APP. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：81 / 89
页数：9
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