The Impact of Environmental Factors in Influencing Epigenetics Related to Oxidative States in the Cardiovascular System

被引：30

作者：

Angelini, Francesco ^{[1
]}

Pagano, Francesca ^{[1
]}

Bordin, Antonella ^{[1
]}

Milan, Marika ^{[2
]}

Chimenti, Isotta ^{[1
]}

Peruzzi, Mariangela ^{[1
]}

Valenti, Valentina ^{[3
]}

Marullo, Antonino ^{[1
]}

Schirone, Leonardo ^{[1
]}

Palmerio, Silvia ^{[1
]}

Sciarretta, Sebastiano ^{[1
,4
]}

Murdoch, Colin E. ^{[5
]}

Frati, Giacomo ^{[1
,4
]}

De Falco, Elena ^{[1
]}

机构：

[1] Sapienza Univ Rome, Dept Med Surg Sci & Biotechnol, Latina, Italy

[2] CNR, Inst Cell Biol & Neurobiol, Rome, Italy

[3] Osped Pediat Bambino Gesu, Dept Radiol, Rome, Italy

[4] IRCCS NeuroMed, Dept AngioCardioNeurol, I-86077 Pozzilli, Italy

[5] Aston Univ, Aston Med Sch, Aston Med Res Inst, Birmingham B4 7ET, W Midlands, England

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2017年 / 2017卷

关键词：

INFLAMMATORY GENE-EXPRESSION; ISCHEMIA-REPERFUSION INJURY; FOXO TRANSCRIPTION FACTORS; INDUCED INSULIN-RESISTANCE; RETRACTED ARTICLE. SEE; HISTONE DEACETYLASE; ADIPOSE-TISSUE; NADPH OXIDASE; CARDIAC-HYPERTROPHY; NITRIC-OXIDE;

D O I：

10.1155/2017/2712751

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Oxidative states exert a significant influence on a wide range of biological and molecular processes and functions. When their balance is shifted towards enhanced amounts of free radicals, pathological phenomena can occur, as the generation of reactive oxygen species (ROS) in tissue microenvironment or in the systemic circulation can be detrimental. Epidemic chronic diseases of western societies, such as cardiovascular disease, obesity, and diabetes correlate with the imbalance of redox homeostasis. Current advances in our understanding of epigenetics have revealed a parallel scenario showing the influence of oxidative stress as a major regulator of epigenetic gene regulation via modification of DNA methylation, histones, and microRNAs. This has provided both the biological link and a potential molecular explanation between oxidative stress and cardiovascular/metabolic phenomena. Accordingly, in this review, we will provide current insights on the physiological and pathological impact of changes in oxidative states on cardiovascular disorders, by specifically focusing on the influence of epigenetic regulation. A special emphasis will highlight the effect on epigenetic regulation of human's current life habits, external and environmental factors, including food intake, tobacco, air pollution, and antioxidant-based approaches. Additionally, the strategy to quantify oxidative states in humans in order to determine which biological marker could best match a subject's profile will be discussed.

引用

页数：18

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