LKB1 and Mammalian Target of Rapamycin As Predictive Factors for the Anticancer Efficacy of Metformin

被引：44

作者：

Memmott, Regan M. ^{[1
]}

Dennis, Phillip A. ^{[1
]}

机构：

[1] NCI, Med Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2009年 / 27卷 / 34期

关键词：

PEUTZ-JEGHERS-SYNDROME; BREAST-CANCER; GENE; KINASE; CELLS;

D O I：

10.1200/JCO.2009.25.3963

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：E226 / E226

页数：1

共 9 条

[1] Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells [J].

Dowling, Ryan J. O. ;

Zakikhani, Mahvash ;

Fantus, I. George ;

Pollak, Michael ;

Sonenberg, Nahum .

CANCER RESEARCH, 2007, 67 (22) :10804-10812

[2] Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome [J].

Esteller, M ;

Avizienyte, E ;

Corn, PG ;

Lothe, RA ;

Baylin, SB ;

Aaltonen, LA ;

Herman, JG .

ONCOGENE, 2000, 19 (01) :164-168

[3] Metformin in Breast Cancer: Time for Action [J].

Goodwin, Pamela J. ;

Ligibel, Jennifer A. ;

Stambolic, Vuk .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (20) :3271-3273

[4] A serine/threonine kinase gene defective in Peutz-Jegheus syndrome [J].

Hemminki, A ;

Markie, D ;

Tomlinson, I ;

Avizienyte, E ;

Roth, S ;

Loukola, A ;

Bignell, G ;

Warren, W ;

Aminoff, M ;

Höglund, P ;

Järvinen, H ;

Kristo, P ;

Pelin, K ;

Ridanpää, M ;

Salovaara, R ;

Toro, T ;

Bodmer, W ;

Olschwang, S ;

Olsen, AS ;

Stratton, MR ;

de la Chapelle, A ;

Aaltonen, LA .

NATURE, 1998, 391 (6663) :184-187

[5] Metformin and Pathologic Complete Responses to Neoadjuvant Chemotherapy in Diabetic Patients With Breast Cancer [J].

Jiralerspong, Sao ;

Palla, Shana L. ;

Giordano, Sharon H. ;

Meric-Bernstam, Funda ;

Liedtke, Cornelia ;

Barnett, Chad M. ;

Hsu, Limin ;

Hung, Mien-Chie ;

Hortobagyi, Gabriel N. ;

Gonzalez-Angulo, Ana M. .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (20) :3297-3302

[6] Dietary Energy Balance Modulates Signaling through the Akt/Mammalian Target of Rapamycin Pathways in Multiple Epithelial Tissues [J].

Moore, Tricia ;

Beltran, Linda ;

Carbajal, Steve ;

Strom, Sara ;

Traag, Jeanine ;

Hursting, Stephen D. ;

DiGiovanni, John .

CANCER PREVENTION RESEARCH, 2008, 1 (01) :65-76

[7] A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome [J].

Sanchez-Cespedes, M. .

ONCOGENE, 2007, 26 (57) :7825-7832

[8]

Shen Z, 2002, CLIN CANCER RES, V8, P2085

[9] Phosphorylation of LKB1 at serine 428 by protein kinase C-ζ is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells [J].

Xie, Zhonglin ;

Dong, Yunzhou ;

Scholz, Roland ;

Neumann, Dietbert ;

Zou, Ming-Hui .

CIRCULATION, 2008, 117 (07) :952-962

← 1 →