Targeting ras signalling pathways in cancer therapy

被引：2511

作者：

Downward, J ^{[1
]}

机构：

[1] Canc Res UK, London Res Inst, London WC2A 3PX, England

来源：

NATURE REVIEWS CANCER | 2003年 / 3卷 / 01期

关键词：

D O I：

10.1038/nrc969

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The RAS proteins control signalling pathways that are key regulators of several aspects of normal cell growth and malignant transformation. They are aberrant in most human tumours due to activating mutations in the RAS genes themselves or to alterations in upstream or downstream signalling components. Rational therapies that target the RAS pathways might inhibit tumour growth, survival and spread. Several of these new therapeutic agents are showing promise in the clinic and many more are being developed.

引用

页码：11 / 22

页数：12

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