1,5-diphenyl-1,4-pentadiene-3-ones and cyclic analogues as antioxidative agents. Synthesis and structure-activity relationship

被引：105

作者：

Sardjiman, SS

Reksohadiprodjo, MS

Hakim, L

vanderGoot, H

Timmerman, H

机构：

[1] FREE UNIV AMSTERDAM,LEIDEN AMSTERDAM CTR DRUG RES,DEPT PHARMACOCHEM,NL-1081 HV AMSTERDAM,NETHERLANDS

[2] GADJAH MADA UNIV,FAC PHARM,YOGYAKARTA,INDONESIA

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1997年 / 32卷 / 7-8期

关键词：

diphenylpentadienone; dibenzylidenecyclohexanone; dibenzylidenecyclopentanone; curcumin; antioxidant; lipid peroxidation;

D O I：

10.1016/S0223-5234(97)83288-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 1,5-diphenyl-1,4-pentadiene-3-ones and cyclic analogues with OH-groups in the pam position of the phenyl rings and various meta substituents were prepared and their antioxidant activity compared with that of curcumin. Most of them exhibited potent antioxidative activity, especially when all the meta positions were substituted by methoxy groups.

引用

页码：625 / 630

页数：6

共 13 条

[1] CHAIN-BREAKING PHENOLIC ANTIOXIDANTS - STERIC AND ELECTRONIC EFFECTS IN POLYALKYLCHROMANOLS, TOCOPHEROL ANALOGS, HYDROQUINONES, AND SUPERIOR ANTIOXIDANTS OF THE POLYALKYLBENZOCHROMANOL AND NAPHTHOFURAN CLASS [J].