Roles of E6 and E7 Human Papillomavirus Proteins in Molecular Pathogenesis of Cervical Cancer

被引：33

作者：

Taghizadeh, Eskandar ^{[1
,2
]}

Jahangiri, Sepideh ^{[3
]}

Rostami, Daryoush ^{[4
]}

Taheri, Forough ^{[5
]}

Renani, Pedram Ghorbani ^{[5
]}

Taghizadeh, Hassan ^{[2
]}

Hayat, Seyed Mohammad Gheibi ^{[6
]}

机构：

[1] Mashhad Univ Med Sci, Fac Med, Dept Med Genet, Mashhad, Razavi Khorasan, Iran

[2] Yasuj Univ Med Sci, Cellular & Mol Res Ctr, Yasuj, Iran

[3] Tarbiat Modares Univ, Fac Biol Sci, Dept Genet, Tehran, Iran

[4] Zabol Univ Med Sci, Dept Sch Allied, Zabol, Iran

[5] Islamic Azad Univ, Shahrekord Branch, Shahrekord, Iran

[6] Shahid Sadoughi Univ Med Sci, Sch Med, Dept Med Genet, Yazd, Iran

来源：

CURRENT PROTEIN & PEPTIDE SCIENCE | 2019年 / 20卷 / 09期

关键词：

Human papillomavirus; cervical cancer; E6/E7; proteins; oncoprotein; cancer cells; pathogenicity; GROWTH-FACTOR RECEPTOR; TYPE-16; E6; MEDIATED DEGRADATION; CELL-PROLIFERATION; LIFE-CYCLE; HPV-16; EXPRESSION; AUTOPHAGY; P53; ONCOPROTEINS;

D O I：

10.2174/1389203720666190618101441

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human papillomavirus (HPV) cancers are expected to be major global health concerns in the upcoming decades. The growth of HPV-positive cancer cells depends on the consistent expression of oncoprotein which has been poorly taken into account in the cellular communication. Among them, E6/E7 oncoproteins are attractive therapeutic targets as their inhibition rapidly leads to the onset of aging in HPV-positive cancer cells. This cellular response is associated with the regeneration of p53, pRb anti-proliferative proteins as well as the mTOR signaling pathway; hence, the identification of involved and application of E6/E7 inhibitors can lead to new therapeutic strategies. In the present review, we focused on the pathogenicity of E6/E7 Proteins of human papillomavirus and their roles associated with the cervical cancer.

引用

页码：926 / 934

页数：9

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