Roles of E6 and E7 Human Papillomavirus Proteins in Molecular Pathogenesis of Cervical Cancer

被引：32

作者：

Taghizadeh, Eskandar ^{[1
,2
]}

Jahangiri, Sepideh ^{[3
]}

Rostami, Daryoush ^{[4
]}

Taheri, Forough ^{[5
]}

Renani, Pedram Ghorbani ^{[5
]}

Taghizadeh, Hassan ^{[2
]}

Hayat, Seyed Mohammad Gheibi ^{[6
]}

机构：

[1] Mashhad Univ Med Sci, Fac Med, Dept Med Genet, Mashhad, Razavi Khorasan, Iran

[2] Yasuj Univ Med Sci, Cellular & Mol Res Ctr, Yasuj, Iran

[3] Tarbiat Modares Univ, Fac Biol Sci, Dept Genet, Tehran, Iran

[4] Zabol Univ Med Sci, Dept Sch Allied, Zabol, Iran

[5] Islamic Azad Univ, Shahrekord Branch, Shahrekord, Iran

[6] Shahid Sadoughi Univ Med Sci, Sch Med, Dept Med Genet, Yazd, Iran

来源：

CURRENT PROTEIN & PEPTIDE SCIENCE | 2019年 / 20卷 / 09期

关键词：

Human papillomavirus; cervical cancer; E6/E7; proteins; oncoprotein; cancer cells; pathogenicity; GROWTH-FACTOR RECEPTOR; TYPE-16; E6; MEDIATED DEGRADATION; CELL-PROLIFERATION; LIFE-CYCLE; HPV-16; EXPRESSION; AUTOPHAGY; P53; ONCOPROTEINS;

D O I：

10.2174/1389203720666190618101441

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human papillomavirus (HPV) cancers are expected to be major global health concerns in the upcoming decades. The growth of HPV-positive cancer cells depends on the consistent expression of oncoprotein which has been poorly taken into account in the cellular communication. Among them, E6/E7 oncoproteins are attractive therapeutic targets as their inhibition rapidly leads to the onset of aging in HPV-positive cancer cells. This cellular response is associated with the regeneration of p53, pRb anti-proliferative proteins as well as the mTOR signaling pathway; hence, the identification of involved and application of E6/E7 inhibitors can lead to new therapeutic strategies. In the present review, we focused on the pathogenicity of E6/E7 Proteins of human papillomavirus and their roles associated with the cervical cancer.

引用

页码：926 / 934

页数：9

共 114 条

[1] Primary Screening for Cervical Cancer Based on High-Risk Human Papillomavirus (HPV) Detection and HPV 16 and HPV 18 Genotyping, in Comparison to Cytology [J].

Agorastos, Theodoros ;

Chatzistamatiou, Kimon ;

Katsamagkas, Taxiarchis ;

Koliopoulos, George ;

Daponte, Alexandros ;

Constantinidis, Theocharis ;

Constantinidis, Theodoros C. .

PLOS ONE, 2015, 10 (03)

[2] IDENTIFICATION OF THE HPV-16 E6 PROTEIN FROM TRANSFORMED MOUSE CELLS AND HUMAN CERVICAL-CARCINOMA CELL-LINES [J].

ANDROPHY, EJ ;

HUBBERT, NL ;

SCHILLER, JT ;

LOWY, DR .

EMBO JOURNAL, 1987, 6 (04) :989-992

[3]

Athinarayanan S., 2016, DETECTION CLASSIFICA

[4] The Potential Value of the PI3K/Akt/mTOR Signaling Pathway for Assessing Prognosis in Cervical Cancer and as a Target for Therapy [J].

Bahrami, Afsane ;

Hasanzadeh, Malihe ;

Hassanian, Seyed Mahdi ;

ShahidSales, Soodabeh ;

Ghayour-Mobarhan, Majid ;

Ferns, Gordon A. ;

Avan, Amir .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2017, 118 (12) :4163-4169

[5] Examination of the pRb-dependent and pRb-independent functions of E7 in vivo [J].

Balsitis, S ;

Dick, F ;

Lee, D ;

Farrell, L ;

Hyde, RK ;

Griep, AE ;

Dyson, N ;

Lambert, PF .

JOURNAL OF VIROLOGY, 2005, 79 (17) :11392-11402

[6] IDENTIFICATION OF HUMAN PAPILLOMAVIRUS TYPE-18 E6-POLYPEPTIDE IN CELLS DERIVED FROM HUMAN CERVICAL CARCINOMAS [J].

BANKS, L ;

SPENCE, P ;

ANDROPHY, E ;

HUBBERT, N ;

MATLASHEWSKI, G ;

MURRAY, A ;

CRAWFORD, L .

JOURNAL OF GENERAL VIROLOGY, 1987, 68 :1351-1359

[7] Overexpression of the c-Met/HGF receptor and its prognostic significance in uterine cervix carcinomas [J].

Baykal, C ;

Ayhan, A ;

Al, A ;

Yüce, K ;

Ayhan, A .

GYNECOLOGIC ONCOLOGY, 2003, 88 (02) :123-129

[8] Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells [J].

Bedoui, Sammy ;

Whitney, Paul G. ;

Waithman, Jason ;

Eidsmo, Liv ;

Wakim, Linda ;

Caminschi, Irina ;

Allan, Rhys S. ;

Wojtasiak, Magdalena ;

Shortman, Ken ;

Carbone, Francis R. ;

Brooks, Andrew G. ;

Heath, William R. .

NATURE IMMUNOLOGY, 2009, 10 (05) :488-495

[9] p53-mediated activation of miRNA34 candidate tumor-suppressor genes [J].

Bommer, Guido T. ;

Gerin, Isabelle ;

Feng, Ying ;

Kaczorowski, Andrew J. ;

Kuick, Rork ;

Love, Robert E. ;

Zhai, Yali ;

Giordano, Thomas J. ;

Qin, Zhaohui S. ;

Moore, Bethany B. ;

MacDougald, Ormond A. ;

Cho, Kathleen R. ;

Fearon, Eric R. .

CURRENT BIOLOGY, 2007, 17 (15) :1298-1307

[10] Integrated genomic and molecular characterization of cervical cancer [J].

Burk, Robert D. ;

Chen, Zigui ;

Saller, Charles ;

Tarvin, Katherine ;

Carvalho, Andre L. ;

Scapulatempo-Neto, Cristovam ;

Silveira, Henrique C. ;

Fregnani, Jose H. ;

Creighton, Chad J. ;

Anderson, Matthew L. ;

Castro, Patricia ;

Wang, Sophia S. ;

Yau, Christina ;

Benz, Christopher ;

Robertson, A. Gordon ;

Mungall, Karen ;

Lim, Lynette ;

Bowlby, Reanne ;

Sadeghi, Sara ;

Brooks, Denise ;

Sipahimalani, Payal ;

Mar, Richard ;

Ally, Adrian ;

Clarke, Amanda ;

Mungall, Andrew J. ;

Tam, Angela ;

Lee, Darlene ;

Chuah, Eric ;

Schein, Jacqueline E. ;

Tse, Kane ;

Kasaian, Katayoon ;

Ma, Yussanne ;

Marra, Marco A. ;

Mayo, Michael ;

Balasundaram, Miruna ;

Thiessen, Nina ;

Dhalla, Noreen ;

Carlsen, Rebecca ;

Moore, Richard A. ;

Holt, Robert A. ;

Jones, Steven J. M. ;

Wong, Tina ;

Pantazi, Angeliki ;

Parfenov, Michael ;

Kucherlapati, Raju ;

Hadjipanayis, Angela ;

Seidman, Jonathan ;

Kucherlapati, Melanie ;

Ren, Xiaojia ;

Xu, Andrew W. .

NATURE, 2017, 543 (7645) :378-+

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