One-pot process to Z-α-benzoylamino-acrylic acid methyl esters via potassium phosphate-catalyzed Erlenmeyer reaction

被引：27

作者：

Cleary, Thomas ^{[1
]}

Brice, Jodie ^{[1
]}

Kennedy, Nicole ^{[1
]}

Chavez, Flavio ^{[1
]}

机构：

[1] Roche Carolina Inc, PTDA FL, Florence, SC 29506 USA

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 04期

关键词：

Erlenmeyer reaction; Acrylic acids; Oxazolones; UNUSUAL AMINO-ACIDS; ASYMMETRIC HYDROGENATION; DERIVATIVES; ISOMERS;

D O I：

10.1016/j.tetlet.2009.11.081

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical and efficient two reaction sequence one-pot process for the synthesis of Z-alpha-benzoylaminoacrylic acid methyl esters was developed. The process involves a potassium phosphate-catalyzed Erlenmeyer reaction of aromatic aldehydes with hippuric acid followed by an oxazolone ring-opening methanolysis. This process afforded a good overall yield and an excellent product quality via a simple workup. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：625 / 628

页数：4

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