Inflammation, adipokines and obesity

被引：16
作者：
Clement, K. [1 ,3 ,4 ]
Vignes, S. [2 ]
机构：
[1] Hop La Pitie Salpetriere, AP HP, Serv Nutr, F-75013 Paris, France
[2] Hop Cognacq Jay, Ctr Natl Reference Malad Vasc Rares, Unite Lymphol, F-75015 Paris, France
[3] INSERM, Equipe 7, U872, F-75006 Paris, France
[4] Univ Paris 06, Ctr Rech Cordeliers, UMRS 872, F-75006 Paris, France
来源：
REVUE DE MEDECINE INTERNE | 2009年 / 30卷 / 09期
关键词：
Obesity; Inflammation; Adipokines; HUMAN ADIPOSE-TISSUE; NECROSIS-FACTOR-ALPHA; SERUM-AMYLOID-A; PLASMINOGEN-ACTIVATOR INHIBITOR-1; INDUCED INSULIN-RESISTANCE; INDUCED WEIGHT-LOSS; HUMAN ADIPOCYTES; MACROPHAGE INFILTRATION; RECEPTOR ANTAGONIST; GENE-EXPRESSION;
D O I：
10.1016/j.revmed.2009.03.363
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In obese Subjects, there is a "low grade" inflammatory state characterized by the moderate but chronic systemic rise of a panel of molecules (adipokines), which carry Out, in addition to pro- or anti-inflammatory actions, several immune or metabolic functions, associated with a macrophagic infiltration in adipose tissue. These two factors provide a better understanding of the pathophysiology of obesity and its potential metabolic, cardiovascular or hepatic complications. A small or even moderate reduction of weight significantly reduces circulating inflammatory markers, modulates adipose tissue profile of inflammatory genes and the risks associated with obesity. (C) 2009 Societe nationale francaise de medecine interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：824 / 832
页数：9
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