Heteroatom doped blue luminescent carbon dots as a nano-probe for targeted cell labeling and anticancer drug delivery vehicle

被引:86
作者
Das, Poushali [1 ]
Ganguly, Sayan [2 ]
Agarwal, Tarun [3 ]
Maity, Pritiprasanna [4 ]
Ghosh, Sabyasachi [2 ]
Choudhary, Sumita [5 ]
Gangopadhyay, Subhashis [5 ]
Maiti, Tapas Kumar [3 ]
Dhara, Santanu [4 ]
Banerjee, Susanta [1 ,6 ]
Das, Narayan Chandra [1 ,2 ]
机构
[1] Indian Inst Technol, Sch Nanosci & Technol, Kharagpur 721302, W Bengal, India
[2] Indian Inst Technol, Rubber Technol Ctr, Kharagpur 721302, W Bengal, India
[3] Indian Inst Technol, Dept Biotechnol, Kharagpur 721302, W Bengal, India
[4] Indian Inst Technol, Sch Med Sci & Technol, Kharagpur 721302, W Bengal, India
[5] Birla Inst Technol & Sci, Dept Phys, Pilani 333031, Rajasthan, India
[6] Indian Inst Technol, Mat Sci Ctr, Kharagpur 721302, W Bengal, India
关键词
Carbon dots; Photoluminescence; Cellular imaging; Drug delivery; Invisible marker; GRAPHENE QUANTUM DOTS; GREEN; PHOTOLUMINESCENCE; NANOPARTICLES; FUTURE; STATE; IONS;
D O I
10.1016/j.matchemphys.2019.121860
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Herein, a simple and efficient method to fabricate nitrogen and sulphur doped photoluminescent carbon dots (C-dots) has been judiciously developed for targeting cancer cells. Advancement in newfangled imaging tool for cancer cells is a vital and highly trustworthy strategy for cancer therapy. The fluorescent C-dots prepared from kappa-carrageenan and folic acid can serve as an efficient cargo for cancer cell labeling expressing the folate receptor on their surface. The prepared C-dots unveiled good water solubility, excellent photostability, and biocompatibility. The C-dots played the role of nano-vehicle for anticancer drug capecitabine under different pH environments. Also, C-dots were applied as invisible marker and finger print recovery applications. The folate receptor in C-dots led to amazing targetability of cancer cells and which embraces a great promise in biomedical studies.
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页数:10
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