Solid state and solubility study of a potential anticancer drug-drug molecular salt of diclofenac and metformin

被引：15
|
作者：
Feng, Wen-Quan [1 ,2 ]
Wang, Ling-Yang [1 ,2 ]
Gao, Jie [1 ,2 ]
Zhao, Ming-Yu [1 ,2 ]
Li, Yan-Tuan [1 ,2 ,3 ]
Wu, Zhi-Yong [1 ,2 ]
Yan, Cui-Wei [1 ,2 ]
机构：
[1] Ocean Univ China, Sch Med & Pharm, Qingdao 266003, Shandong, Peoples R China
[2] Ocean Univ China, Coll Marine Life Sci, Qingdao 266003, Shandong, Peoples R China
[3] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266003, Peoples R China
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2021年 / 1234卷
基金：
中国国家自然科学基金;
关键词：
Diclofenac; Metformin; Drug-drug molecular salt; Anticancer; Hirshfeld surface analysis; AMORPHOUS SALTS; CRYSTALLINE; APOPTOSIS;
D O I：
10.1016/j.molstruc.2021.130166
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
To improve the physicochemical properties of diclofenac (DFA) and exert its potential anti-tumor effect in combined pharmacotherapy of metformin (MET), a new drug-drug molecular salt of DFA and MET (DFAMET) is formed and characterized. The single-crystal X-ray diffraction analysis shows that DFA-MET is a three-dimensional (3D) supramolecular structure constructed by different hydrogen-bonding interactions between DFA and MET with 1:1 stoichiometry by proton transfer reaction. In addition, Hirshfeld Surface analysis shows that both the hydrogen-bonding interactions and the Vander Waals maintain the 3D supramolecular structure of DFA-MET together. Compared with pure DFA and pure diclofenac sodium (NaDFA), the dissolving behavior and permeability of DFA-MET by forming drug-drug molecular salt in physiological pH environments are enhanced remarkably. Published by Elsevier B.V.
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页数：8
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