Seducing astrocytes to the dark side

被引：25

作者：

Burda, Joshua E. ^{[1
]}

Sofroniew, Michael V. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA

来源：

CELL RESEARCH | 2017年 / 27卷 / 06期

关键词：

D O I：

10.1038/cr.2017.37

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

After injury and in disease of the central nervous system (CNS), local cells called astrocytes respond with diverse molecular changes whose functional consequences are incompletely understood. A combined genomic and experimental analysis shows that classically-activated microglia, which are innate immune cells resident in CNS neural tissue, release molecules that drive astrocytes into a neurotoxic state, raising important questions about potential adaptive and maladaptive functions of such a mechanism.

引用

页码：726 / 727

页数：2

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