Pulmonary function in multiple sclerosis without any respiratory complaints

被引:33
作者
Altintas, Ayse
Demir, Tuncalp
Ikitimur, Hande Demirel
Yildirim, Nurhayat
机构
[1] Istanbul Univ, Cerrahpasa Med Fac, Dept Neurol, Istanbul, Turkey
[2] Istanbul Univ, Cerrahpasa Med Fac, Dept Pulm Dis, Istanbul, Turkey
关键词
multiple sclerosis; respiratory muscle function; pulmonary function tests; diffusion;
D O I
10.1016/j.clineuro.2006.09.004
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objectives: Pulmonary complications in severe multiple sclerosis (MS) are often seen secondary to respiratory muscle dysfunction. The development of respiratory muscle dysfunction and its association with disability during the course of MS is unknown. In our study,we investigated the predictive value of respiratory muscle functions and the change in forced vital capacity (Delta forced vital capacity [FVC]; FVC upright - FVC supine) to detect deterioration of respiratory muscle functions in the early phase of MS. Patients and Methods: Twenty-one MS patients with a median age of 34.5 +/- 9.45 years were enrolled. Fourteen cases were relapsing-remitting, six were secondary progressive, one was primary progressive type. The mean duration of disease was 10.76 +/- 6.6 years. Seventeen healthy subjects with a median age of 40.7 +/- 7.6 years were chosen as a control group. Smoking habit was similar in both groups. Pulmonary function tests (PFT), lung volumes, diffusion, respiratory muscle function (P-Imax, P-Emax), mouth occlusion pressure, and indirect sign of respiratory center function (P-0.1) tests were performed. PFT were repeated in supine and upright positions. Results: Our results in the MS group and the control group, respectively, were: diffusion (DLc,): 18.8 +/- 4.2 vs. 26.4 +/- 7.3 mL/mmHg/min), P-Imax (82.1 +/- 26.3 vs. 109.1 +/- 23.3 cmH(2)O), P-Emax (119.2 +/- 42 vs. 171.8 +/- 50.2 cmH(2)O), P-0.1 (2.6 +/- 0.7 vs. 4.2 +/- 0.7). All parameters were lower in the MS group compared with the control group (p < 0.05). In the MS group, FVC values in the upright position were higher than FVC values in the supine position. The difference in FVC values in MS patients between the upright and supine positions (Delta FVC) was also found to be significantly higher than in the control group (Delta FVC 262.3 +/- 247.6 (MS), 98.8 +/- 179.1 mL (CONTROL)) (p < 0.01). Conclusion: Our results indicate the presence of pulmonary dysfunction in MS even in the absence of any respiratory symptoms. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:242 / 246
页数:5
相关论文
共 19 条
[1]   Electrophysiologic techniques for the assessment of respiratory muscle function [J].
Aldrich, TK ;
Sinderby, C ;
McKenzie, DK ;
Estenne, M ;
Gandevia, SC .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2002, 166 (04) :548-+
[3]   LUNG-FUNCTION TESTING - SELECTION OF REFERENCE VALUES AND INTERPRETATIVE STRATEGIES [J].
不详 .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1991, 144 (05) :1202-1218
[4]  
[Anonymous], 1995, AM J RESP CRIT CARE, V152, P2185
[5]  
BLACK LF, 1969, AM REV RESPIR DIS, V99, P696
[6]  
BROWN PW, 1994, CERAM ENG SCI P, V15, P729
[7]   Respiratory dysfunction in multiple sclerosis: A prospective analysis of 60 patients [J].
Buyse, B ;
Demedts, M ;
Meekers, J ;
Vandegaer, L ;
Rochette, F ;
Kerkhofs, L .
EUROPEAN RESPIRATORY JOURNAL, 1997, 10 (01) :139-145
[8]   Respiratory muscle involvement in multiple sclerosis [J].
Gosselink, R ;
Kovacs, L ;
Decramer, M .
EUROPEAN RESPIRATORY JOURNAL, 1999, 13 (02) :449-454
[9]   Respiratory muscle weakness and respiratory muscle training in severely disabled multiple sclerosis patients [J].
Gosselink, R ;
Kovacs, L ;
Ketelaer, P ;
Carton, H ;
Decramer, M .
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION, 2000, 81 (06) :747-751
[10]  
Hyatt RE, 2003, INTERPRETATION PULMO, P5