The rhodium-catalysed 1,2-addition of arylboronic acids to aldehydes and ketones with sulfonated S-Phos

被引：30

作者：

White, James R. ^{[1
]}

Price, Gareth J. ^{[1
]}

Plucinski, Pawel K. ^{[2
]}

Frost, Christopher G. ^{[1
]}

机构：

[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

[2] Univ Bath, Dept Chem Engn, Bath BA2 7AY, Avon, England

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 52期

基金：

英国工程与自然科学研究理事会;

关键词：

CROSS-COUPLING REACTIONS; ALKENYLBORONIC ACIDS; ASYMMETRIC ADDITION; AQUEOUS SOLVENTS; SUZUKI-MIYAURA; BORONIC ACIDS; LIGANDS; WATER; COORDINATION; REACTIVITY;

D O I：

10.1016/j.tetlet.2009.10.082

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The rhodium-catalysed 1,2-addition of arylboronic acids to aryl aldehydes has been accomplished in high yield using sulfonated S-Phos, a water-soluble biaryl phosphine ligand which allows for catalyst recycling. The catalytic protocol has also been successful in the challenging arylation of ketones. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：7365 / 7368

页数：4

共 36 条

[1] General catalysts for the Suzuki-Miyaura and Sonogashira coupling reactions of aryl chlorides and for the coupling of challenging substrate combinations in water [J].