A study of brain metabolism in fibromyalgia by positron emission tomography

被引：5

作者：

Usui, Chie ^{[1
]}

Soma, Tsutomu ^{[2
,3
]}

Hatta, Kotaro ^{[1
]}

Aratani, Satoko ^{[4
]}

Fujita, Hidetoshi ^{[4
]}

Nishioka, Kenya ^{[5
]}

Machida, Yutaka ^{[5
]}

Kuroiwa, Yoshiyuki ^{[6
,7
]}

Nakajima, Toshihiro ^{[4
]}

Nishioka, Kusuki ^{[4
]}

机构：

[1] Juntendo Univ, Nerima Hosp, Dept Psychiat, Nerima Ku, 3-1-10 Takanodai, Tokyo 1778521, Japan

[2] Univ Tokyo, Grad Sch Med, Dept Radiol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan

[3] FUJIFILM RI Pharma Co Ltd, Qual Assurance Dept, QMS Grp, Chuo Ku, 2-14-1 Kyobashi, Tokyo 1040031, Japan

[4] Tokyo Med Univ, Inst Innovat Med Sci & Educ, Shinjyuku Ku, 6-1-1 Shinjyuku, Tokyo 1608402, Japan

[5] Juntendo Univ, Sch Med, Dept Neurol, Bunkyo Ku, 2-1-1 Hongo, Tokyo 1138421, Japan

[6] Teikyo Univ, Sch Med, Mizonokuchi Hosp, Dept Neurol,Takatsu Ku, 3-8-3 Mizonokuchi, Kawasaki, Kanagawa 2138507, Japan

[7] Teikyo Univ, Sch Med, Mizonokuchi Hosp, Stroke Ctr,Takatsu Ku, 3-8-3 Mizonokuchi, Kawasaki, Kanagawa 2138507, Japan

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2017年 / 75卷

关键词：

Brain metabolism; Fibromyalgia; Pain; Positron emission tomography; Prognosis; DIAGNOSTIC-CRITERIA; PAIN; THERAPY; FMRI;

D O I：

10.1016/j.pnpbp.2017.01.012

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Purpose: The aim of the present study was to determine the brain regions with altered metabolism in patients with treatment-na ve fibromyalgia (FM). Methods: We used [F-18] fluoro-D-glucose positron emission tomography to examine a total of 18 treatment-na ve FM patients and 18 age-and sex-matched healthy controls not suffering from pain. A voxel-by-voxel group analysis was performed using statistical parametric mapping. Results: No significant voxel (peak)-level results were detected in this study; however, some regions were detected as significant-size clusters. There were no significant differences in brain metabolism between FM patients and controls. However, the right thalamus and left lentiform nucleus were hypermetabolic areas in FM patients with poor prognosis compared to the healthy controls. In contrast, the left insula and left lentiform nucleus were hypometabolic areas in FM patients with good prognosis compared to the healthy controls. Compared to FM patients with good prognosis, FM patients with poor prognosis showed significant hypermetabolism in the left thalamus, bilateral lentiform nucleus, and right parahippocampal gyrus. Conclusion: The present findings suggest an association between the metabolism in the thalamus, lentiform nucleus, and parahippocampal gyrus and prognosis in FM patients. Further study with a larger number of patients is required to confirm this association. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：120 / 127

页数：8

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