Regulation of Gene Expression in Peripheral T Cells by Runx Transcription Factors

被引：21
作者：
Djuretic, Ivana M. [1 ,2 ,3 ]
Cruz-Guilloty, Fernando [1 ,2 ,3 ]
Rao, Anjana [1 ,2 ,3 ]
机构：
[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
[2] Childrens Hosp, Immune Dis Inst, Boston, MA 02115 USA
[3] Childrens Hosp, Program Cellular & Mol Med, Boston, MA 02115 USA
来源：
ADVANCES IN IMMUNOLOGY, VOL 104 | 2009年 / 104卷
关键词：
ROR-GAMMA-T; HELPER TYPE-1 CELLS; TGF-BETA; OSTEOBLAST DIFFERENTIATION; NONCODING RNAS; HUMAN LEUKEMIA; IL4; SILENCER; HUMAN GENOME; DNA-BINDING; CBF-BETA;
D O I：
10.1016/S0065-2776(08)04001-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Members of the Runx family of transcription factors, Runx1-3, are essential regulators of the immune system: a deficiency in one of the members, Runx1, results in complete ablation of hematopoiesis, and all three Runx proteins play important, nonredundant roles in immune system development and function. Here, we review gene regulation by Runx proteins in T lymphocytes, with a focus on their recently emerging roles in the development and function of peripheral CD4(+) and CD8(+) T lineages.
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页码：1 / 23
页数：23
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