COVID-19 and thrombosis: From bench to bedside

被引：138
|
作者：
Ali, Mohammad A. M. [1 ]
Spinler, Sarah A. [2 ]
机构：
[1] SUNY Binghamton, Sch Pharm & Pharmaceut Sci, Dept Pharmaceut Sci, Binghamton, NY USA
[2] SUNY Binghamton, Sch Pharm & Pharmaceut Sci, Dept Pharm Practice, Binghamton, NY USA
来源：
TRENDS IN CARDIOVASCULAR MEDICINE | 2021年 / 31卷 / 03期
关键词：
RENIN-ANGIOTENSIN SYSTEM; ENDOTHELIAL-CELLS; FACTOR-VIII; ACE2; EXPRESSION; COMPLICATIONS;
D O I：
10.1016/j.tcm.2020.12.004
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Coronavirus disease of 2019 (COVID-19) is the respiratory viral infection caused by the coronavirus SARS-CoV2 (Severe Acute Respiratory Syndrome Coronavirus 2). Despite being a respiratory illness, COVID-19 is found to increase the risk of venous and arterial thromboembolic events. Indeed, the link between COVID-19 and thrombosis is attracting attention from the broad scientific community. In this review we will analyze the current available knowledge of the association between COVID-19 and thrombosis. We will highlight mechanisms at both molecular and cellular levels that may explain this association. In addition, the article will review the antithrombotic properties of agents currently utilized or being studied in COVID-19 management. Finally, we will discuss current professional association guidance on prevention and treatment of thromboembolism associated with COVID-19. Published by Elsevier Inc.
引用
收藏
页码：143 / 160
页数：18
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