New bioactive rosigenin analogues and aromatic polyketide metabolites from the freshwater aquatic fungus Massarina tunicata

被引：56

作者：

Oh, H

Swenson, DC

Gloer, JB ^{[1
]}

Shearer, CA

机构：

[1] Univ Iowa, Dept Chem, Iowa City, IA 52242 USA

[2] Univ Illinois, Dept Plant Biol, Urbana, IL 61801 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 01期

关键词：

D O I：

10.1021/np020342d

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new rosigenin analogues (massarigenins A-D; 1-4) and two new aromatic polyketide-derived secondary metabolites (massarinins A and B; 6, 7) and have been isolated from the freshwater aquatic fungus Massarina tunicata. The structures of these compounds were determined primarily by analysis of NMR data, and that of compound 1 was verified by X-ray crystallography. The known compound 4-(2-hydroxybutynoxy)benzoic acid (11) was also obtained, and its absolute stereochemistry was assigned. Several of these metabolites showed antibiotic activity against Gram-positive bacteria.

引用

页码：73 / 79

页数：7

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