Materials engineering for immunomodulation

被引：467

作者：

Hubbell, Jeffrey A. ^{[1
,2
]}

Thomas, Susan N. ^{[1
]}

Swartz, Melody A. ^{[1
,2
]}

机构：

[1] Ecole Polytech Fed Lausanne, Inst Bioengn, CH-1015 Lausanne, Switzerland

[2] Ecole Polytech Fed Lausanne, Inst Chem Sci & Engn, CH-1015 Lausanne, Switzerland

来源：

NATURE | 2009年 / 462卷 / 7272期

关键词：

DENDRITIC-CELL SUBSETS; LIVING EMULSION POLYMERIZATION; IN-VIVO; COMPLEMENT ACTIVATION; BLOCK-COPOLYMER; DNA VACCINATION; IMMUNE-RESPONSE; LYMPH-NODES; T-CELLS; ANTIGEN;

D O I：

10.1038/nature08604

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The engineering of materials that can modulate the immune system is an emerging field that is developing alongside immunology. For therapeutic ends such as vaccine development, materials are now being engineered to deliver antigens through specific intracellular pathways, allowing better control of the way in which antigens are presented to one of the key types of immune cell, T cells. Materials are also being designed as adjuvants, to mimic specific 'danger' signals in order to manipulate the resultant cytokine environment, which influences how antigens are interpreted by T cells. In addition to offering the potential for medical advances, immunomodulatory materials can form well-defined model systems, helping to provide new insight into basic immunobiology.

引用

页码：449 / 460

页数：12

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