MicroRNA nomenclature and the need for a revised naming prescription

被引:56
作者
Budak, Hikmet [1 ]
Bulut, Reyyan [2 ]
Kantar, Melda [2 ]
Alptekin, Burcu [2 ]
机构
[1] Sabanci Univ, Plant Genet & Genom, TR-34956 Tuzla, Turkey
[2] Sabanci Univ, Mol Biol Genet & Bioengn Program, TR-34956 Tuzla, Turkey
关键词
microRNAs; isomiRNAs; mitomiRs; cipomiRs; bona fide miRNAs; canonical miRNAs; SMALL RNAS; EXPRESSION; DISCOVERY; DATABASE; HISTORY; MIRNAS;
D O I
10.1093/bfgp/elv026
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A central environment and interface for microRNA (miRNA) registry and repository and a general standardized framework for their systematic annotation was established over a decade ago. However, the numbers of experimentally and computationally identified miRNAs are swiftly accumulating, and new aspects of miRNA-mediated gene regulation are being revealed. Currently, it is of great significance that the annotation framework should be redefined to include newly discovered miRNA species such as the variants of mature miRNAs (isomiRNAs), and organellar miRNAs: cipomiRNAs and mitomiRNAs. It is also of great importance that key terminology referring to the novelty, evolutionary history or biogenesis of miRNAs, as well as the confidence of their identification are standardized in the literature and disseminated in a central miRNA registry. Here, we review the status of miRNA nomenclature, curation and critical points of need for a revision of miRNA nomenclature and terminology.
引用
收藏
页码:65 / 71
页数:7
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