Cortical contributions to the auditory frequency-following response revealed by MEG

被引：281

作者：

Coffey, Emily B. J. ^{[1
,2
,3
]}

Herholz, Sibylle C. ^{[1
,2
,3
,4
]}

Chepesiuk, Alexander M. P. ^{[1
]}

Baillet, Sylvain ^{[1
,2
]}

Zatorre, Robert J. ^{[1
,2
,3
]}

机构：

[1] McGill Univ, Montreal Neurol Inst, 3801 Univ St, Montreal, PQ H3A 2B4, Canada

[2] CRBLM, Montreal, PQ H3G 2A8, Canada

[3] Int Lab Brain Mus & Sound Res BRAMS, Montreal, PQ, Canada

[4] German Ctr Neurodegenerat Dis DZNE, D-53175 Bonn, Germany

来源：

NATURE COMMUNICATIONS | 2016年 / 7卷

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

HUMAN BRAIN-STEM; AUTISM SPECTRUM DISORDERS; MUSICAL EXPERIENCE; PITCH PERCEPTION; AGING AFFECTS; SPEECH; CORTEX; REPRESENTATION; STIMULATION; PLASTICITY;

D O I：

10.1038/ncomms11070

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The auditory frequency-following response (FFR) to complex periodic sounds is used to study the subcortical auditory system, and has been proposed as a biomarker for disorders that feature abnormal sound processing. Despite its value in fundamental and clinical research, the neural origins of the FFR are unclear. Using magnetoencephalography, we observe a strong, right-asymmetric contribution to the FFR from the human auditory cortex at the fundamental frequency of the stimulus, in addition to signal from cochlear nucleus, inferior colliculus and medial geniculate. This finding is highly relevant for our understanding of plasticity and pathology in the auditory system, as well as higher-level cognition such as speech and music processing. It suggests that previous interpretations of the FFR may need re-examination using methods that allow for source separation.

引用

页数：11

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