Methylene Blue Dye, an Accurate Dye for Sentinel Lymph Node Identification in Early Breast Cancer

被引：0

作者：

Mathelin, Carole ^{[1
]}

Croce, Sabrina ^{[5
]}

Brasse, David

Gairard, Beatrice ^{[2
]}

Gharbi, Mouslim ^{[1
]}

Andriamisandratsoa, Norosoa ^{[3
]}

Bekaert, Virgile ^{[6
,7
]}

Francis, Ziad ^{[6
,7
]}

Guyonnet, Jean-Louis ^{[6
,7
]}

Huss, Daniel ^{[6
,7
]}

Salvador, Samuel ^{[6
,7
]}

Schaeffer, Roland ^{[4
]}

Grucker, Daniel ^{[3
]}

Marin, Cristi ^{[5
]}

Bellocq, Jean-Pierre ^{[5
]}

机构：

[1] CHRU, Unite Senol, F-67091 Strasbourg, France

[2] CHRU, Dept Oncohematol, F-67091 Strasbourg, France

[3] CHRU, Nucl Med Serv, Hop Civil, F-67091 Strasbourg, France

[4] CHRU, Nucl Med Serv, Dept Anesthesiol, F-67091 Strasbourg, France

[5] CHRU, Hop Hautepierre, Dept Pathol, F-67098 Strasbourg, France

[6] CNRS, UMR 7178, IN2P3, Inst Pluridisciplinaire Hubert Curien, F-67037 Strasbourg 02, France

[7] ULP, F-67037 Strasbourg 02, France

来源：

ANTICANCER RESEARCH | 2009年 / 29卷 / 10期

关键词：

Breast cancer; gamma probe; lymphoscintigraphy; methylene blue dye; sentinel lymph node; ESTROGEN-RECEPTOR ACTIVITY; ISOSULFAN BLUE; BIOPSY; LOCALIZATION; ANAPHYLAXIS; MASSAGE; INJECTION; SKIN;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: The aim of this prospective study was to analyze the safety of methylene blue dye (MBD) and compare its efficacy with that of isotopic mapping for sentinel lymph node (SLN) identification in breast cancer. Patients and Methods: The SLN procedure, involving isotopic mapping and MBD (subareolar intraparenchymal injections of 2 mL, 10 mg/mL), was performed on 100 patients with early breast cancer. Results: The procedure was safe with a success rate of 99%; SLNs were, respectively, found in 65% by MBD, in 73% by lymphoscintigraphy and in 94% by gamma-probe. Out of 40 metastatic SLNs, 37 were "hot" and 32 stained. Digital examination allowed the detection of 2 additional metastatic LNs. Conclusion: MBD is safe and combination mapping associated with digital examination is the superior method. Modification of the procedure, favouring injections of dilute MBD (4 mL, 1.25 mg/mL) increases MBD efficiency (90%) and maintains low rates of complications.

引用

页码：4119 / 4125

页数：7

共 45 条

[21] Anaphylaxis to patent blue dye during sentinel lymph node biopsy for breast cancer [J].