Epithelial-Mesenchymal Transitions in Development and Disease

被引：8799
作者：
Thiery, Jean Paul [1 ,2 ,3 ]
Acloque, Herve [4 ]
Huang, Ruby Y. J. [1 ,3 ,5 ]
Angela Nieto, M. [4 ]
机构：
[1] ASTAR, IMCB, Singapore 138673, Singapore
[2] Ctr Expt Therapeut, Singapore 138669, Singapore
[3] Natl Univ Singapore, Canc Sci Inst, Singapore 117456, Singapore
[4] Inst Neurociencias CSIC UMH, Alacant 03550, Spain
[5] Natl Univ Singapore Hosp, Dept Obstet & Gynaecol, Singapore 119074, Singapore
来源：
CELL | 2009年 / 139卷 / 05期
关键词：
EPIDERMAL-GROWTH-FACTOR; CANCER STEM-CELLS; NF-KAPPA-B; TRANSCRIPTION FACTOR SNAIL; PERITONEAL MESOTHELIAL CELLS; GENE REGULATORY NETWORK; NEURAL CREST; E-CADHERIN; TGF-BETA; DOWN-REGULATION;
D O I：
10.1016/j.cell.2009.11.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The epithelial to mesenchymal transition (EMT) plays crucial roles in the formation of the body plan and in the differentiation of multiple tissues and organs. EMT also contributes to tissue repair, but it can adversely cause organ fibrosis and promote carcinoma progression through a variety of mechanisms. EMT endows cells with migratory and invasive properties, induces stem cell properties, prevents apoptosis and senescence, and contributes to immunosuppression. Thus, the mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis. © 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：871 / 890
页数：20
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