In Vivo Production of RNA Aptamers and Nanoparticles: Problems and Prospects

被引：4

作者：

Al Shanaa, Ousama ^{[1
,2
]}

Rumyantsev, Andrey ^{[1
]}

Sambuk, Elena ^{[1
]}

Padkina, Marina ^{[1
]}

机构：

[1] St Petersburg State Univ, Dept Genet & Biotechnol, St Petersburg 199034, Russia

[2] Atom Energy Commiss Syria, POB 6091, Damascus, Syria

来源：

MOLECULES | 2021年 / 26卷 / 05期

基金：

俄罗斯基础研究基金会;

关键词：

aptamer; nanoparticles; nucleic acids; nucleic acid nanoparticles; ENDOTHELIAL GROWTH-FACTOR; PHI29 PRNA NANOPARTICLES; NUCLEIC-ACID APTAMERS; SMALL NONCODING RNAS; STRUCTURAL BASIS; FLUOROPHORE-BINDING; DNA NANOSTRUCTURES; CRYSTAL-STRUCTURE; MALACHITE GREEN; EMERGING FIELD;

D O I：

10.3390/molecules26051422

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RNA aptamers are becoming increasingly attractive due to their superior properties. This review discusses the early stages of aptamer research, the main developments in this area, and the latest technologies being developed. The review also highlights the advantages of RNA aptamers in comparison to antibodies, considering the great potential of RNA aptamers and their applications in the near future. In addition, it is shown how RNA aptamers can form endless 3-D structures, giving rise to various structural and functional possibilities. Special attention is paid to the Mango, Spinach and Broccoli fluorescent RNA aptamers, and the advantages of split RNA aptamers are discussed. The review focuses on the importance of creating a platform for the synthesis of RNA nanoparticles in vivo and examines yeast, namely Saccharomyces cerevisiae, as a potential model organism for the production of RNA nanoparticles on a large scale.

引用

页数：19

共 163 条

[1] Pharmacological Characterization of Chemically Synthesized Monomeric phi29 pRNA Nanoparticles for Systemic Delivery [J].

Abdelmawla, Sherine ;

Guo, Songchuan ;

Zhang, Limin ;

Pulukuri, Sai M. ;

Patankar, Prithviraj ;

Conley, Patrick ;

Trebley, Joseph ;

Guo, Peixuan ;

Li, Qi-Xiang .

MOLECULAR THERAPY, 2011, 19 (07) :1312-1322

[2] Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis [J].

Adams, D. ;

Gonzalez-Duarte, A. ;

O'Riordan, W. D. ;

Yang, C. -C. ;

Ueda, M. ;

Kristen, A. V. ;

Tournev, I. ;

Schmidt, H. H. ;

Coelho, T. ;

Berk, J. L. ;

Lin, K. -P. ;

Vita, G. ;

Attarian, S. ;

Plante-Bordeneuve, V. ;

Mezei, M. M. ;

Campistol, J. M. ;

Buades, J. ;

Brannagan, T. H., III ;

Kim, B. J. ;

Oh, J. ;

Parman, Y. ;

Sekijima, Y. ;

Hawkins, P. N. ;

Solomon, S. D. ;

Polydefkis, M. ;

Dyck, P. J. ;

Gandhi, P. J. ;

Goyal, S. ;

Chen, J. ;

Strahs, A. L. ;

Nochur, S. V. ;

Sweetser, M. T. ;

Garg, P. P. ;

Vaishnaw, A. K. ;

Gollob, J. A. ;

Suhr, O. B. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 379 (01) :11-21

[3] Opportunities, Barriers, and a Strategy for Overcoming Translational Challenges to Therapeutic Nucleic Acid Nanotechnology [J].

Afonin, Kirill A. ;

Dobrovolskaia, Marina A. ;

Church, George ;

Bathe, Mark .

ACS NANO, 2020, 14 (08) :9221-9227

[4]

Afonin KA, 2010, NAT NANOTECHNOL, V5, P676, DOI [10.1038/NNANO.2010.160, 10.1038/nnano.2010.160]

[5] Current advances in aptamer-assisted technologies for detecting bacterial and fungal toxins [J].

Alizadeh, N. ;

Memar, M. Y. ;

Mehramuz, B. ;

Abibiglou, S. S. ;

Hemmati, F. ;

Kafil, H. Samadi .

JOURNAL OF APPLIED MICROBIOLOGY, 2018, 124 (03) :644-651

[6] Imaging of RNA in live cells [J].

Armitage, Bruce A. .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2011, 15 (06) :806-812

[7] Advancements in Nucleic Acid Based Therapeutics against Respiratory Viral Infections [J].

Asha, Kumari ;

Kumar, Prashant ;

Sanicas, Melvin ;

Meseko, Clement A. ;

Khanna, Madhu ;

Kumar, Binod .

JOURNAL OF CLINICAL MEDICINE, 2019, 8 (01)

[8] Fluorogenic RNA Mango aptamers for imaging small non-coding RNAs in mammalian cells [J].

Autour, Alexis ;

Jeng, Sunny C. Y. ;

Cawte, Adam D. ;

Abdolahzadeh, Amir ;

Galli, Angela ;

Panchapakesan, Shanker S. S. ;

Rueda, David ;

Ryckelynck, Michael ;

Unrau, Peter J. .

NATURE COMMUNICATIONS, 2018, 9

[9] Role of Small Noncoding RNAs in Bacterial Metabolism [J].

Azhikina, T. L. ;

Ignatov, D. V. ;

Salina, E. G. ;

Fursov, M. V. ;

Kaprelyants, A. S. .

BIOCHEMISTRY-MOSCOW, 2015, 80 (13) :1633-1646

[10]

Baker BR, 2006, J AM CHEM SOC, V128, P3138, DOI 10.1021/ja056957p

← 1 2 3 4 5 6 7 8 9 10 →