The unique role of proprotein convertase subtilisin/kexin 9 in cholesterol homeostasis

被引：87

作者：

Mousavi, S. A. ^{[1
]}

Berge, K. E. ^{[1
]}

Leren, T. P. ^{[1
]}

机构：

[1] Natl Hosp Norway, Oslo Univ Hosp, Med Genet Lab, Dept Med Genet, NO-0027 Oslo, Norway

来源：

JOURNAL OF INTERNAL MEDICINE | 2009年 / 266卷 / 06期

关键词：

clathrin-mediated endocytosis; LDL uptake; LDL receptor; PCSK9; plasma LDL cholesterol; DENSITY-LIPOPROTEIN-RECEPTOR; AUTOSOMAL-DOMINANT HYPERCHOLESTEROLEMIA; LDL RECEPTOR; SECRETED PCSK9; FAMILIAL HYPERCHOLESTEROLEMIA; HEPG2; CELLS; LIVER-REGENERATION; PLASMA-CHOLESTEROL; ADAPTER PROTEIN; TARGET GENES;

D O I：

10.1111/j.1365-2796.2009.02167.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The LDL receptor (LDLR) plays an essential role in the regulation of plasma (LDL) cholesterol concentrations by virtue of its ability to clear plasma LDL. Down-regulation of the LDLR by proprotein convertase subtilisin/kexin 9 (PCSK9) has recently emerged as a regulatory mechanism that controls plasma LDL cholesterol concentrations. Studies in which PCSK9 is over-expressed in mice, have demonstrated that PCSK9, by enhancing hepatic LDLR degradation, decreases the availability of the LDLR for LDL uptake, resulting in increased plasma LDL cholesterol levels. However, PCSK9 has also recently been shown to mediate down-regulation of surface receptors other than the LDLR, suggesting that it may have much broader roles than initially thought.

引用

页码：507 / 519

页数：13

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