Is HIV-1 evolving to a less virulent form in humans?

被引：144
作者：
Arien, Kevin K.
Vanham, Guido
Arts, Eric J.
机构：
[1] Inst Trop Med, Dept Microbiol, HIV & Retrovirol Res Unit, B-2000 Antwerp, Belgium
[2] Case Western Reserve Univ, Dept Med, Div Infect Dis, Cleveland, OH 44195 USA
来源：
NATURE REVIEWS MICROBIOLOGY | 2007年 / 5卷 / 02期
关键词：
D O I：
10.1038/nrmicro1594
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
During the rapid spread of HIV-1 in humans, the main ( M) group of HIV-1 has evolved into ten distinct subtypes, undergone countless recombination events and diversified extensively. The impact of this extreme genetic diversity on the phenotype of HIV-1 has only recently become a research focus, but early findings indicate that the dominance of HIV-1 subtype C in the current epidemic might be related to the lower virulence of this subtype compared with other subtypes. Here, we explore whether HIV-1 has reached peak virulence or has already started the slow path to attenuation.
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页码：141 / 151
页数：11
相关论文
共 164 条
[1]  
ANDERSON R M, 1991
[2]  
ANDERSON RM, 1989, ANN NY ACAD SCI, V569, P240, DOI 10.1111/j.1749-6632.1989.tb27374.x
[3]  
[Anonymous], 2000, The Spatial and Temporal Dynamics of Host-Parasitoid Interactions
[4]   The history of SIVS and AIDS: Epidemiology, phylogeny and biology of isolates from naturally SIV infected non-human primates (NHP) in Africa [J].
Apetrei, C ;
Robertson, DL ;
Marx, PA .
FRONTIERS IN BIOSCIENCE-LANDMARK, 2004, 9 :225-254
[5]   Replicative fitness of historical and recent HIV-1 isolates suggests HIV-1 attenuation over time [J].
Ariën, KK ;
Troyer, RA ;
Gali, Y ;
Colebunders, RL ;
Arts, EJ ;
Vanham, G .
AIDS, 2005, 19 (15) :1555-1564
[6]   The replicative fitness of primary human immunodeficiency virus type 1 (HIV-1) group M, HIV-1 group O, and HIV-2 isolates [J].
Ariën, KK ;
Abraha, A ;
Quiñones-Mateu, ME ;
Kestens, L ;
Vanham, G ;
Arts, EJ .
JOURNAL OF VIROLOGY, 2005, 79 (14) :8979-8990
[7]   Sorting out the complexities of HIV-1 fitness [J].
Arts, EJ ;
Quiñones-Mateu, ME .
AIDS, 2003, 17 (05) :780-781
[8]  
ARTS EJ, 2006, 16 INT AIDS C TOR CA
[9]   HIV-1 group O infection in Cameroon, 1986-1998 [J].
Ayouba, A ;
Mauclère, P ;
Martin, PMV ;
Cunin, P ;
Mfoupouendoun, J ;
Njinku, B ;
Souquières, S ;
Simon, F .
EMERGING INFECTIOUS DISEASES, 2001, 7 (03) :466-467
[10]   Comparing the ex vivo fitness of CCR5-tropic human immunodeficiency virus type 1 isolates of subtypes B and C [J].
Ball, SC ;
Abraha, A ;
Collins, KR ;
Marozsan, AJ ;
Baird, H ;
Quiñones-Mateu, ME ;
Penn-Nicholson, A ;
Murray, M ;
Richard, N ;
Lobritz, M ;
Zimmerman, PA ;
Kawamura, T ;
Blauvelt, A ;
Arts, EJ .
JOURNAL OF VIROLOGY, 2003, 77 (02) :1021-1038
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