Structures and mechanisms of the mycothiol biosynthetic enzymes

被引：42

作者：

Fan, Fan ^{[1
]}

Vetting, Matthew W. ^{[1
]}

Frantom, Patrick A. ^{[1
]}

Blanchard, John S. ^{[1
]}

机构：

[1] Yeshiva Univ Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2009年 / 13卷 / 04期

关键词：

MYCOBACTERIUM-TUBERCULOSIS ERDMAN; CYSTEINE LIGASE MSHC; CRYSTAL-STRUCTURE; 2-AMINO-2-DEOXY-ALPHA-D-GLUCOPYRANOSIDE LIGASE; CONFORMATIONAL-CHANGE; SMEGMATIS MUTANTS; DEACETYLASE MSHB; SYNTHASE MUTANT; GENE; ANTIBIOTICS;

D O I：

10.1016/j.cbpa.2009.07.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the past decade, the genes encoding all four enzymes responsible for the biosynthesis of mycothiol in Mycobacterium tuberculosis have been identified. Orthologs of each of these have been stably expressed and structurally characterized. The chemical mechanisms of all the four have also been studied. Because of the unique phylogenetic distribution of mycothiol, and the enzymes responsible for its biosynthesis, these enzymes represent interesting potential targets for antimycobacterial agents.

引用

页码：451 / 459

页数：9

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