Determination of a potential antitumor quassinoid in rat plasma by UPLC-MS/MS and its application in a pharmacokinetic study

被引：7

作者：

Zhang, Qiang ^{[1
]}

Yuan, Yonghui ^{[2
]}

Cui, Jianchun ^{[3
]}

Xiao, Tingting ^{[4
]}

Deng, Zhipeng ^{[5
]}

Jiang, Daqing ^{[1
]}

机构：

[1] Liaoning Canc Hosp & Inst, Breast Surg, Shenyang 110042, Peoples R China

[2] Liaoning Canc Hosp & Inst, Dept Infect, Shenyang 110042, Peoples R China

[3] Peoples Hosp Liaoning Prov, Dept Endocrine Surg, Shenyang 110016, Peoples R China

[4] Hong Kong Baptist Univ, Sch Chinese Med, Kowloon Tong, Hong Kong, Peoples R China

[5] Shandong Acad Med Sci, Inst Mat Med, Jinan 250062, Peoples R China

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2016年 / 124卷

关键词：

Brusatol; Quassinoid; Rat plasma; UPLC-MS/MS; Pharmacokinetic study; CELL-DIFFERENTIATION; BRUSATOL;

D O I：

10.1016/j.jpba.2016.02.046

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A sensitive UPLC-MS/MS method was developed and validated for the determination of brusatol in rat plasma. Chromatographic separation was carried out on a C-18 column using methanol and 10 mM ammonium acetate containing 0.1% (v/v) formic acid (55:45, v/v). The lower limit of quantification (LLOQ) was 1.0 ng/mL for brusatol in plasma. The intra- and inter-day precision for the analyte ranged from 3.2% to 9.2% and 1.3% to 7.8%, and the accuracy was between 97.3% and 108.5%. The method was successfully applied in a pharmacokinetic study of brusatol following intravenous injection (0.5, 1.0, and 2.0 mg/kg) of brusatol. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：143 / 148

页数：6

共 15 条

[1] Brusatol-induced HL-60 cell differentiation involves NF-κB activation [J].

Cuendet, M ;

Gills, JJ ;

Pezzuto, JM .

CANCER LETTERS, 2004, 206 (01) :43-50

[2] Chemical constituents from Brucea java']javanica [J].

Dong, Shi-Hui ;

Liu, Jia ;

Ge, Ying-Zi ;

Dong, Lei ;

Xu, Cheng-Hui ;

Ding, Jian ;

Yue, Jian-Min .

PHYTOCHEMISTRY, 2013, 85 :175-184

[3]

Li X., 1987, J SHENYANG COLL PHAR, V4, P262

[4]

Lin H., 2006, CHIN J EXP TRAD MED, V12, P65

[5] A new triterpenoid from Brucea java']javanica [J].

Liu, Jian Hua ;

Qin, Jiang Jiang ;

Jin, Hui Zi ;

Hu, Xiao Jia ;

Chen, Ming ;

Shen, Yun Heng ;

Yan, Shi Kai ;

Zhang, Wei Dong .

ARCHIVES OF PHARMACAL RESEARCH, 2009, 32 (05) :661-666

[6] Bioactive Quassinoids from the Seeds of Brucea java']javanica [J].

Liu, Jun-Hong ;

Zhao, Nan ;

Zhang, Gui-Jie ;

Yu, Shi-Shan ;

Wu, Li-Jun ;

Qu, Jing ;

Ma, Shuang-Gang ;

Chen, Xiao-Guang ;

Zhang, Tian-Qi ;

Bai, Jian ;

Chen, Hui ;

Fang, Zhen-Feng ;

Zhao, Fen ;

Tang, Wei-Bin .

JOURNAL OF NATURAL PRODUCTS, 2012, 75 (04) :683-688

[7]

[刘丽 LIU Li], 2006, [沈阳药科大学学报, Journal of Shenyang Pharmaceutical University], V23, P580

[8] Brusatol-mediated induction of leukemic cell differentiation and G1 arrest is associated with down-regulation of c-myc [J].

Mata-Greenwood, E ;

Cuendet, M ;

Sher, D ;

Gustin, D ;

Stock, W ;

Pezzuto, JM .

LEUKEMIA, 2002, 16 (11) :2275-2284

[9] Hypoglycemic effect of quassinoids from Brucea java']javanica (L.) Merr (Simaroubaceae) seeds [J].

NoorShahida, Ajmi ;

Wong, Tin Wui ;

Choo, Chee Yan .

JOURNAL OF ETHNOPHARMACOLOGY, 2009, 124 (03) :586-591

[10] Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2 [J].

Olayanju, Adedamola ;

Copple, Ian M. ;

Bryan, Holly K. ;

Edge, George T. ;

Sison, Rowena L. ;

Wong, Min Wei ;

Lai, Zheng-Quan ;

Lin, Zhi-Xiu ;

Dunn, Karen ;

Sanderson, Christopher M. ;

Alghanem, Ahmad F. ;

Cross, Michael J. ;

Ellis, Ewa C. ;

Ingelman-Sundberg, Magnus ;

Malik, Hassan Z. ;

Kitteringham, Neil R. ;

Goldring, Christopher E. ;

Park, B. Kevin .

FREE RADICAL BIOLOGY AND MEDICINE, 2015, 78 :202-212

← 1 2 →