Activity-Based NIR Enzyme Fluorescent Probes for the Diagnosis of Tumors and Image-Guided Surgery

被引：315
作者：
Li, Haidong [1 ]
Kim, Dayeh [1 ]
Yao, Qichao [2 ]
Ge, Haoying [2 ]
Chung, Jeewon [1 ]
Fan, Jiangli [2 ,3 ]
Wang, Jingyun [4 ]
Peng, Xiaojun [2 ,3 ]
Yoon, Juyoung [1 ]
机构：
[1] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea
[2] Dalian Univ Technol, State Key Lab Fine Chem, Hitech Zone, 2 Linggong Rd, Dalian 116024, Peoples R China
[3] Dalian Univ Technol, Ningbo Inst, 26 Yucai Rd, Ningbo 315016, Peoples R China
[4] Dalian Univ Technol, Sch Bioengn, Hitech Zone, 2 Linggong Rd, Dalian 116024, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2021年 / 60卷 / 32期
基金：
新加坡国家研究基金会; 美国国家科学基金会;
关键词：
enzyme activity; image-guided surgery; near-infrared activation; tumors; GAMMA-GLUTAMYL-TRANSPEPTIDASE; LEUCINE AMINOPEPTIDASE ACTIVITY; BETA-GALACTOSIDASE ACTIVITY; GLUTATHIONE-S-TRANSFERASE; INDUCED LIVER-INJURY; REAL-TIME TRACKING; LONG-TERM TRACKING; IN-VIVO; ALKALINE-PHOSPHATASE; TURN-ON;
D O I：
10.1002/anie.202009796
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Near-infrared (NIR) activatable fluorescent probes have been considered to be the effective edge tools for the investigation of cell biology and disease diagnosis because of their outstanding advantages. Related genes involved in tumor genesis and progression regulate the overexpression of certain enzymes. Owing to the distinctive characteristics of quick reaction time and favorable pharmacokinetics, enzyme-reactive NIR optical probes have shown great potential in the diagnosis of tumorigenesis and in image-guided intraoperative surgeries with high signal-to-noise ratios. In this review, we mainly summarize the latest advancements in enzyme-reactive NIR fluorescent probes from design strategy to biomedical application. Specifically, some challenges and prospects in this field are presented at the end of the review, which will be beneficial to innovatively construct new multifunctional fluorescent probes and actively promote their clinical transformation in the future.
引用
收藏
页码：17268 / 17289
页数：22
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