Oxidative stress-modulating drugs have preferential anticancer effects - involving the regulation of apoptosis, DNA damage, endoplasmic reticulum stress, autophagy, metabolism, and migration

被引：168

作者：

Tang, Jen-Yang ^{[1
,2
]}

Fu Ou-Yang ^{[3
,4
]}

Hou, Ming-Feng ^{[3
,4
,5
,6
]}

Huang, Hurng-Wern ^{[7
]}

Wang, Hui-Ru ^{[7
]}

Li, Kun-Tzu ^{[8
]}

Fayyaz, Sundas ^{[9
]}

Shu, Chih-Wen ^{[10
]}

Chang, Hsueh-Wei ^{[5
,8
,11
]}

机构：

[1] Kaohsiung Med Univ, Coll Med, Fac Med, Dept Radiat Oncol, Kaohsiung, Taiwan

[2] Kaohsiung Med Univ Hosp, Dept Radiat Oncol, Kaohsiung, Taiwan

[3] Kaohsiung Med Univ Hosp, Div Breast Surg, Kaohsiung, Taiwan

[4] Kaohsiung Med Univ Hosp, Dept Surg, Kaohsiung, Taiwan

[5] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Canc Ctr, Kaohsiung, Taiwan

[6] Kaohsiung Med Univ, Inst Clin Med, Kaohsiung, Taiwan

[7] Natl Sun Yat Sen Univ, Inst Biomed Sci, Kaohsiung, Taiwan

[8] Kaohsiung Med Univ, Dept Biomed Sci & Environm Biol, Kaohsiung, Taiwan

[9] RLMC, Lab Translat Oncol & Personalized Med, Lahore, Pakistan

[10] I Shou Univ, Sch Med Int Students, Kaohsiung, Taiwan

[11] Kaohsiung Med Univ, Ctr Canc Res, Kaohsiung, Taiwan

来源：

SEMINARS IN CANCER BIOLOGY | 2019年 / 58卷

关键词：

Preferential killing; Oxidative stress; Redox homeostasis; Function; Anticancer drugs; UNFOLDED PROTEIN RESPONSE; INDUCED CELL-DEATH; EPITHELIAL-MESENCHYMAL TRANSITION; BREAST-CANCER CELLS; HEPATOCELLULAR-CARCINOMA CELLS; SMALL-MOLECULE; IONIZING-RADIATION; SIGNALING PATHWAY; DEPENDENT PATHWAY; TUMOR-CELLS;

D O I：

10.1016/j.semcancer.2018.08.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To achieve preferential effects against cancer cells but less damage to normal cells is one of the main challenges of cancer research. In this review, we explore the roles and relationships of oxidative stress-mediated apoptosis, DNA damage, ER stress, autophagy, metabolism, and migration of ROS-modulating anticancer drugs. Understanding preferential anticancer effects in more detail will improve chemotherapeutic approaches that are based on ROS-modulating drugs in cancer treatments.

引用

页码：109 / 117

页数：9

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