Endocrine disruptors in female reproductive tract development and carcinogenesis

被引：67

作者：

Ma, Liang ^{[1
,2
]}

机构：

[1] Washington Univ, Dept Med, Div Dermatol, St Louis, MO 63110 USA

[2] Washington Univ, Dept Dev Biol, St Louis, MO 63110 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2009年 / 20卷 / 07期

基金：

美国国家卫生研究院;

关键词：

ESTROGEN-RECEPTOR-ALPHA; NEONATAL DIETHYLSTILBESTROL EXPOSURE; DIFFERENTIAL EXPRESSION PATTERNS; UTERINE GENE-EXPRESSION; MULLERIAN DUCT; IN-UTERO; MOUSE UTERUS; EPITHELIAL DIFFERENTIATION; UROGENITAL DEVELOPMENT; BETA-CATENIN;

D O I：

10.1016/j.tem.2009.03.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Growing concerns over endocrine disrupting chemicals (EDCs) and their effects on human fetal development and adult health have promoted research into the underlying molecular mechanisms of endocrine disruption. Gene targeting technology has allowed insight into the genetic pathways governing reproductive tract development and how exposure to EDCs during a critical developmental window can alter reproductive tract development, potentially forming the basis for adult diseases. This review primarily uses diethylstilbestrol (DES) as a model agent for EDCs and discusses the recent progress elucidating how DES and other EDCs affect murine female reproductive tract development and cancer at the molecular level.

引用

页码：357 / 363

页数：7

共 71 条

[1] Conditional deletion of β-catenin in the mesenchyme of the developing mouse uterus results in a switch to adipogenesis in the myometrium [J].

Arango, NA ;

Szotek, PP ;

Manganaro, TF ;

Oliva, E ;

Donahoe, PK ;

Teixeira, J .

DEVELOPMENTAL BIOLOGY, 2005, 288 (01) :276-283

[2]

Bartol F F, 2006, Soc Reprod Fertil Suppl, V62, P113

[3] In utero diethylstilbestrol (DES) exposure alters Hox gene expression in the developing mullerian system [J].

Block, K ;

Kardana, A ;

Igarashi, P ;

Taylor, HS .

FASEB JOURNAL, 2000, 14 (09) :1101-1108

[4] Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system [J].

Carroll, TJ ;

Park, JS ;

Hayashi, S ;

Majumdar, A ;

McMahon, AP .

DEVELOPMENTAL CELL, 2005, 9 (02) :283-292

[5] Wnt7a is a suppressor of cell death in the female reproductive tract and is required for postnatal and estrogen-mediated growth [J].

Carta, L ;

Sassoon, D .

BIOLOGY OF REPRODUCTION, 2004, 71 (02) :444-454

[6] Impact of estrogen receptor β on gene networks regulated by estrogen receptor α in breast cancer cells [J].

Chang, Edmund C. ;

Frasor, Jonna ;

Komm, Barry ;

Katzenellenbogen, Benita S. .

ENDOCRINOLOGY, 2006, 147 (10) :4831-4842

[7] Estrogen receptor-α-mediates the detrimental effects of neonatal diethylstilbestrol (DES) exposure in the murine reproductive tract [J].

Couse, JF ;

Korach, KS .

TOXICOLOGY, 2004, 205 (1-2) :55-63

[8] Estrogen receptor-α knockout mice exhibit resistance to the developmental effects of neonatal diethylstilbestrol exposure on the female reproductive tract [J].

Couse, JF ;

Dixon, D ;

Yates, M ;

Moore, AB ;

Ma, L ;

Maas, R ;

Korach, KS .

DEVELOPMENTAL BIOLOGY, 2001, 238 (02) :224-238

[9] STROMAL INDUCTION AND SPECIFICATION OF MORPHOGENESIS AND CYTODIFFERENTIATION OF EPITHELIA OF MULLERIAN DUCTS AND UROGENITAL SINUS DURING DEVELOPMENT OF UTERUS AND VAGINA IN MICE [J].

CUNHA, GR .

JOURNAL OF EXPERIMENTAL ZOOLOGY, 1976, 196 (03) :361-369

[10] Mouse Dach1 and Dach2 are redundantly required for Mullerian duct development [J].

Davis, Richard J. ;

Harding, Mark ;

Moayedi, Yalda ;

Mardon, Graeme .

GENESIS, 2008, 46 (04) :205-213

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