Ion Channels, Transporters, and Pumps as Targets for Heart Failure Therapy

被引：5

作者：

Doshi, Darshan ^{[2
]}

Marx, Steven O. ^{[1
,2
]}

机构：

[1] Columbia Univ, Dept Pharmacol, Coll Phys & Surg, New York, NY 10032 USA

[2] Columbia Univ, Div Cardiol, Coll Phys & Surg, Dept Med, New York, NY 10032 USA

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 2009年 / 54卷 / 04期

基金：

美国国家卫生研究院;

关键词：

heart failure; ion channels; transporters; pumps; treatment; arrhythmias; CARDIAC SARCOPLASMIC-RETICULUM; HUMAN DILATED CARDIOMYOPATHY; K-ATP CHANNELS; RYANODINE-RECEPTOR; MYOCARDIAL-INFARCTION; VENTRICULAR MYOCYTES; PKA PHOSPHORYLATION; BINDING-PROTEIN; CA2+ CHANNELS; PHOSPHOLAMBAN;

D O I：

10.1097/FJC.0b013e3181a1b9c7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Congestive heart failure is a leading cause of morbidity and mortality. Congestive heart failure is marked by atrial and ventricular enlargements and reduced cardiac contractility and an association with an increased incidence of atrial and ventricular arrhythmias and sudden cardiac death. Dysfunctional ion channel function is one of the major underlying mechanisms of the reduced contractility and arrhythmias. In this review, we explore the utility of ion channels, transporters, and pumps as targets for the treatment of heart failure, focusing predominantly on the treatment for reduced contractility and arrhythmias.

引用

页码：273 / 278

页数：6

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