The Effects of CCl4 on Na+/K+-ATPase and Trace Elements in Rats

被引：7
作者：
Akyuz, Fahrettin [1 ]
Aydin, Oezlem [1 ]
Demir, Temir Ali [2 ]
Kanbak, Guengoer [1 ]
机构：
[1] Eskisehir Osmangazi Univ, Fac Med, Dept Biochem, TR-26480 Eskisehir, Turkey
[2] Eskisehir Osmangazi Univ, Arts & Sci Fac, Dept Chem, TR-26480 Eskisehir, Turkey
来源：
BIOLOGICAL TRACE ELEMENT RESEARCH | 2009年 / 132卷 / 1-3期
关键词：
CCl4; Na+/K+-ATPase; Ca2+/Mg2+-ATPase; Trace element; Erythrocyte; CCL4-INDUCED LIVER-CIRRHOSIS; LIPID-PEROXIDATION; CARBON; METALLOTHIONEIN; COPPER; OXYGEN; MEMBRANE; DAMAGE; ZINC; HEPATOTOXICITY;
D O I：
10.1007/s12011-009-8395-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
CCl4 is an industrial agent with known toxic effects on the environment. There are so many studies about hepatotoxic effects of CCl4. We herein studied the effects of CCl4 on Na+/K+-ATPase and Ca2+/Mg2+-ATPase activities on erythrocyte membranes and trace element levels of serum erythrocyte and liver tissue of rats. Study was performed on control group (group C, n = 8) and a study group (group S, n = 8) in which CCl4 was given. Na+/K+-ATPase and Ca2+/Mg2+-ATPase were significantly reduced in CCl4-treated group (p < 0.01, p < 0.001). Trace element levels also showed statistically significant differences in CCl4-treated group. Membrane Na+/K+-ATPase and Ca2+/Mg2+-ATPase activities were diminished due to CCl4-induced injury on erythrocyte membranes. CCl4 also changed the trace element levels of serum erythrocyte membrane and liver by altering the mineral substance concentrations.
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收藏
页码：207 / 214
页数：8
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