Ultra-stable and multistimuli-responsive nanoparticles coated with zwitterionic pillar[n]arene for enhanced cellular uptake

被引：11
作者：
Jiao, Yupeng [1 ]
Lan, Shang [1 ]
Ma, Da [1 ]
机构：
[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2021年 / 32卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Host-guest systems; Stimuli responsiveness; Zwitterionic ligands; Gold nanoparticles; Cellular uptake; SURFACES; RESIST;
D O I：
10.1016/j.cclet.2020.08.0011
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Nanoparticle surface property is crucial for circulation stability, cellullar uptake and other biological characteristics. Zwitterionic pillar[n]arenes (ZPns) were used to coat gold nanoparticles (GNPs) via hostguest interaction. The resulting GNPs demonstrated higher stability in blood serum compared to polyethylene glycol (PEG)-coated GNPs. ZPn-coated GNPs were responsive to UV-irradiation, competitive displacement and acidic pH. UV-irradiation or competitive displacement could lead to the removal of ZPn coating to expose GNPs, which enhanced cell uptake efficiency by 5.9- and 7.4-fold, respectively. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1025 / 1028
页数：4
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